Total skin electron beam and total nodal irradiation of cutaneous T-cell lymphoma

Bizhan Micaily, Odette Campbell, Charles Moser, Eric C. Vonderheid, Luther W. Brady

Research output: Contribution to journalArticlepeer-review

Abstract

Nineteen patients with cutaneous T-cell lymphoma (CTCL) limited to the skin and/or lymph nodes were treated at Hahnemann University with a combination of total skin electron beam and total nodal irradiation (TSEB + TNI). The patients were classified as Stage Ib (1 patient), Stage IIa (8 patients), Stage IIb (5 patients), and Stage IVa (5 patients). Treatment resulted in a complete response in 100% ( 14 14) of patients with Stage lb, IIa, and Ilb disease, and a CR in 60% ( 3 5) of patients with Stage IVa disease. The Stage Ib and IIa patients had an overall survival of 100% and a disease-free survival of 44% at 6 years. Four of the five patients with Stage IIb CTCL relapsed within 3 months after completing TSEB + TNI with an overall survival in the group of 40% at 5 years. The Stage IVa patients all relapsed within 7 months and died of their disease within 50 months of completing treatment. The acute effects of TSEB + TNI were well tolerated, but three patients developed second malignancy (lung, kidney and skin) and one patient developed myelodysplasia, possibly the result of radiotherapy.

Original languageEnglish (US)
Pages (from-to)809-813
Number of pages5
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume20
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • Cutaneous T-cell lymphoma
  • Total nodal irradiation
  • Total skin electron beam

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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