Abstract
Sixteen patients with advanced cutaneous T-cell lymphoma (CTCL) with or without lymph node involvement, but without evidence of extranodal manifestations, were treated with a combination of total skin electron beam therapy (TSEB) and total nodal irradiation (TNI). Fourteen (87%) patients achieved a complete response (CR) lasting from 1 to 84+ months (median, 8+ months) from the completion of treatment. The best results occurred in 6 patients with pretumorous intracutaneous CTCL (Stages IB and IIA) where the CR has lasted in all patients from 8 to 84+ months (median about 27+ months). Conversely, a long-term CR occurred in only one of five patients with tumor-phase intracutaneous CTCL (Stage IIB) and in none of the 5 patients with histopathologically proven nodal involvement (Stage IVA). Radiotherapy was well tolerated with the major toxicity being vone marrow suppression. We conclude that combined TSEB and TNI is a relatively safe and effective treatment for patients with CTCL prior to the development of lymph node involvement. Long-term follow-up is needed to assess the curative potential of this treatment.
Original language | English (US) |
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Pages (from-to) | 1111-1115 |
Number of pages | 5 |
Journal | International Journal of Radiation Oncology, Biology, Physics |
Volume | 11 |
Issue number | 6 |
DOIs | |
State | Published - 1985 |
Externally published | Yes |
Keywords
- Cutaneous T-cell lymphoma
- Total body photon irradiation
- Total nodal irradiation
- Total skin electron beam
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation