Total skin electron beam and total nodal irradiation for treatment of patients with cutaneous t-cell lymphoma

Bizhan Micaily, Eric C. vonderheid, Luther W. Brady, Charles Andrews

Research output: Contribution to journalArticlepeer-review

Abstract

Sixteen patients with advanced cutaneous T-cell lymphoma (CTCL) with or without lymph node involvement, but without evidence of extranodal manifestations, were treated with a combination of total skin electron beam therapy (TSEB) and total nodal irradiation (TNI). Fourteen (87%) patients achieved a complete response (CR) lasting from 1 to 84+ months (median, 8+ months) from the completion of treatment. The best results occurred in 6 patients with pretumorous intracutaneous CTCL (Stages IB and IIA) where the CR has lasted in all patients from 8 to 84+ months (median about 27+ months). Conversely, a long-term CR occurred in only one of five patients with tumor-phase intracutaneous CTCL (Stage IIB) and in none of the 5 patients with histopathologically proven nodal involvement (Stage IVA). Radiotherapy was well tolerated with the major toxicity being vone marrow suppression. We conclude that combined TSEB and TNI is a relatively safe and effective treatment for patients with CTCL prior to the development of lymph node involvement. Long-term follow-up is needed to assess the curative potential of this treatment.

Original languageEnglish (US)
Pages (from-to)1111-1115
Number of pages5
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume11
Issue number6
DOIs
StatePublished - 1985
Externally publishedYes

Keywords

  • Cutaneous T-cell lymphoma
  • Total body photon irradiation
  • Total nodal irradiation
  • Total skin electron beam

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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