Total neuropathy score: Validation and reliability study

David Cornblath, Vinay Chaudhry, K. Carter, D. Lee, M. Seysedadr, M. Miernicki, T. Joh

Research output: Contribution to journalArticle

Abstract

Objective: To determine the validity and reliability of the total neuropathy score (TNS) in normal subjects and in subjects with diabetic polyneuropathy. Background: Clinical research in peripheral neuropathy requires validated outcome measures. Multiple outcome measures have been used in clinical trials, including symptom measures, functional scales, quantitative clinical examinations, nerve conduction studies, computerized sensory examinations, and nerve biopsy. Each of these measures has its strengths and weaknesses. In two previous studies of toxic neuropathy from chemotherapeutic agents, the authors used the TNS as the outcome measure. The TNS combines information obtained from grading of symptoms, signs, nerve conduction studies, and quantitative sensory tests, and provides a single measure to quantify neuropathy. Methods: The authors measured the inter- and intrarater reliability of the TNS and preformed a cross-sectional validation study of the TNS and its subscales with the Mayo Clinic measures of neuropathy, neuropathy symptom score (NSS), and the neurologic impairment score (NIS) in five healthy control subjects and 30 individuals with varying severities of diabetic polyneuropathy. Results: Inter- and intrarater reliability of the TNS was excellent (0.966 and 0.986 respectively). The cross-sectional validation study showed excellent correlations among all measures of neuropathy. Conclusions: The total neuropathy score is a validated measure of peripheral nerve function and could be used as an end point for clinical trials of peripheral neuropathy.

Original languageEnglish (US)
Pages (from-to)1660-1664
Number of pages5
JournalNeurology
Volume53
Issue number8
StatePublished - Nov 10 1999

Fingerprint

Validation Studies
Diabetic Neuropathies
Neural Conduction
Outcome Assessment (Health Care)
Peripheral Nervous System Diseases
Cross-Sectional Studies
Clinical Trials
Poisons
Neurologic Manifestations
Peripheral Nerves
Reproducibility of Results
Signs and Symptoms
Healthy Volunteers
Biopsy
Research

Keywords

  • Neuropathy
  • Scales
  • Validation-Diabetes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cornblath, D., Chaudhry, V., Carter, K., Lee, D., Seysedadr, M., Miernicki, M., & Joh, T. (1999). Total neuropathy score: Validation and reliability study. Neurology, 53(8), 1660-1664.

Total neuropathy score : Validation and reliability study. / Cornblath, David; Chaudhry, Vinay; Carter, K.; Lee, D.; Seysedadr, M.; Miernicki, M.; Joh, T.

In: Neurology, Vol. 53, No. 8, 10.11.1999, p. 1660-1664.

Research output: Contribution to journalArticle

Cornblath, D, Chaudhry, V, Carter, K, Lee, D, Seysedadr, M, Miernicki, M & Joh, T 1999, 'Total neuropathy score: Validation and reliability study', Neurology, vol. 53, no. 8, pp. 1660-1664.
Cornblath D, Chaudhry V, Carter K, Lee D, Seysedadr M, Miernicki M et al. Total neuropathy score: Validation and reliability study. Neurology. 1999 Nov 10;53(8):1660-1664.
Cornblath, David ; Chaudhry, Vinay ; Carter, K. ; Lee, D. ; Seysedadr, M. ; Miernicki, M. ; Joh, T. / Total neuropathy score : Validation and reliability study. In: Neurology. 1999 ; Vol. 53, No. 8. pp. 1660-1664.
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