Total Knee Arthroplasty in Ehlers-Danlos Syndrome

Peter S. Rose, Carl A. Johnson, David S. Hungerford, Edward G. McFarland

Research output: Contribution to journalArticlepeer-review


The Ehlers-Danlos syndromes (EDS) are a rare group of connective tissue disorders characterized by severe joint hypermobility and instability. Ten patients with 12 primary knee arthroplasties were identified. Average age at time of surgery was 43.3 years, with follow-up data acquired at an average of 65 months after surgery. Primary indications for surgery were tibiofemoral or patellar instability (n = 8) and arthritis (n = 4). Knee Society Functional scores averaged 29.6 before surgery and 51.3 at time of interview (P<.005). Knee Society Knee scores at time of follow-up evaluation averaged 70. Tibiofemoral and patella stability were significantly improved. Arthroplasty appears to be an effective option for knee arthritis and instability in EDS patients, although results and satisfaction are lower than that reported for conventional arthroplasty indications.

Original languageEnglish (US)
Pages (from-to)190-196
Number of pages7
JournalJournal of Arthroplasty
Issue number2
StatePublished - Feb 2004


  • Ehlers-Danlos syndrome
  • Knee arthroplasty
  • Patella stability
  • Tibiofemoral stability
  • Wound dehiscence

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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