TY - JOUR
T1 - Total Gastrectomy for CDH-1 Mutation Carriers
T2 - An Institutional Experience
AU - DiBrito, Sandra R.
AU - Blair, Alex B.
AU - Prasath, Vishnu
AU - Habibi, Mehran
AU - Harmon, John W.
AU - Duncan, Mark D.
N1 - Funding Information:
Authors' contributions: Conception and design of study was carried out by DiBrito, Blair, Habibi, Harmon, and Duncan. Acquisition and analysis of data was carried out by DiBrito, Blair, Prasath, and Duncan. Interpretation of data was done by DiBrito, Blair, Habibi, Harmon, and Duncan. Drafting, critical revision, and final approval of manuscript and accountability for the work were contributed by DiBrito, Blair, Prasath, Habibi, Harmon, and Duncan. This work was supported in part by NIH T32 CA126607-08 (ABB).
Funding Information:
Authors' contributions: Conception and design of study was carried out by DiBrito, Blair, Habibi, Harmon, and Duncan. Acquisition and analysis of data was carried out by DiBrito, Blair, Prasath, and Duncan. Interpretation of data was done by DiBrito, Blair, Habibi, Harmon, and Duncan. Drafting, critical revision, and final approval of manuscript and accountability for the work were contributed by DiBrito, Blair, Prasath, Habibi, Harmon, and Duncan. This work was supported in part by NIH T32 CA126607-08 (ABB).
Publisher Copyright:
© 2019 The Authors
PY - 2020/3
Y1 - 2020/3
N2 - Background: Gastric cancer is a leading cause of cancer-related death across the world. A subset of gastric cancers demonstrates an inherited genetic predisposition. Individuals with germline mutations in the CDH1 gene incur a lifetime risk for diffuse gastric cancer and benefit from prophylactic gastrectomy. The results for this operative intervention remain relatively undescribed in the literature, despite guidelines supporting its use. Methods: We present a single-institution series of patients with confirmed CDH1 mutations who underwent gastrectomy. We describe their presenting symptoms, preoperative screening, clinicopathologic features, and outcomes. Focal outcomes of interest are weight loss and postoperative morbidity. Results: Between 2010 and 2018, ten patients with a confirmed CDH1 mutation underwent total gastrectomy with intestinal pouch reconstruction at our institution. Two patients had clinical gastric cancer at the time of their operation at 21 and 60 y of age. Eight patients had prophylactic gastrectomy. All prophylactic patients had undergone prior endoscopic screening without detection of cancer; however, three had occult gastric cancer on pathological examination. Median weight loss after gastrectomy was 10 kg at 6 mo and 11 kg at 1 y. Postoperative morbidity was limited to one anastomotic leak, one hematoma, and one case of pneumonia. All patients remain disease-free with median follow-up of 19 mo. Conclusions: Total gastrectomy for patients with a CDH1 mutation is a cancer-preventing operation for a high-risk population. For this series, jejunal pouch reconstruction was performed with encouragingly low postoperative morbidity, weight loss, and good subjective function.
AB - Background: Gastric cancer is a leading cause of cancer-related death across the world. A subset of gastric cancers demonstrates an inherited genetic predisposition. Individuals with germline mutations in the CDH1 gene incur a lifetime risk for diffuse gastric cancer and benefit from prophylactic gastrectomy. The results for this operative intervention remain relatively undescribed in the literature, despite guidelines supporting its use. Methods: We present a single-institution series of patients with confirmed CDH1 mutations who underwent gastrectomy. We describe their presenting symptoms, preoperative screening, clinicopathologic features, and outcomes. Focal outcomes of interest are weight loss and postoperative morbidity. Results: Between 2010 and 2018, ten patients with a confirmed CDH1 mutation underwent total gastrectomy with intestinal pouch reconstruction at our institution. Two patients had clinical gastric cancer at the time of their operation at 21 and 60 y of age. Eight patients had prophylactic gastrectomy. All prophylactic patients had undergone prior endoscopic screening without detection of cancer; however, three had occult gastric cancer on pathological examination. Median weight loss after gastrectomy was 10 kg at 6 mo and 11 kg at 1 y. Postoperative morbidity was limited to one anastomotic leak, one hematoma, and one case of pneumonia. All patients remain disease-free with median follow-up of 19 mo. Conclusions: Total gastrectomy for patients with a CDH1 mutation is a cancer-preventing operation for a high-risk population. For this series, jejunal pouch reconstruction was performed with encouragingly low postoperative morbidity, weight loss, and good subjective function.
KW - CDH1
KW - Familial gastric cancer
KW - Hereditary diffuse gastric cancer
KW - Prophylactic gastrectomy
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U2 - 10.1016/j.jss.2019.09.062
DO - 10.1016/j.jss.2019.09.062
M3 - Article
C2 - 31685251
AN - SCOPUS:85074444386
SN - 0022-4804
VL - 247
SP - 438
EP - 444
JO - Journal of Surgical Research
JF - Journal of Surgical Research
ER -