Total cerebral ischemia: A new model system for the study of post-cardiac arrest brain damage

David L. Jackson, William P. Dole

Research output: Contribution to journalArticle


The pathophysiology of post-cardiac arrest brain damage is not well understood. Many of the model systems presently used to study global ischemia have serious limitations. A new model system for total cerebral ischemia (TCI), using aortic and inferior vena caval occlusion balloons, is described. This model system produces verifiable TCI and avoids surgical invasion of the thorax or the use of vasoactive drugs. It does not impede cerebral venous return and protects the cardiopulmonary system from damage. This model system can be used to study the efficacy of various therapeutic interventions following a standardized CNS global ischemic insult.

Original languageEnglish (US)
Pages (from-to)38-43
Number of pages6
Issue number1
StatePublished - 1979
Externally publishedYes


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this