TY - JOUR
T1 - Topological journey of parasite-derived antigens for presentation by MHC class I molecules
AU - Blanchard, Nicolas
AU - Shastri, Nilabh
N1 - Funding Information:
N.B. was supported by a long-term postdoctoral fellowship from the Human Frontier Science Program Organization. N.S. was partly supported by a Lord Harris Senior Research Fellowship at the Harris Manchester College and the Weatherall Institute of Molecular Medicine at the University of Oxford, UK. Research in the N.S. laboratory is supported by grants (AI060040, AI044864, AI39548, AI065831) from the National Institutes of Health.
PY - 2010/11
Y1 - 2010/11
N2 - Within cells of their host, many bacteria and parasites inhabit specialized compartments, such as a modified phagosome for Mycobacterium tuberculosis or a parasitophorous vacuole for Toxoplasma gondii. These locations could exclude microbial material from entry into the MHC class I surveillance pathway. Remarkably, however, under these circumstances, cells can still signal the presence of invading pathogens to circulating CD8+ T cells, which typically play a key role in protection against such intracellular organisms. Here, we review MHC I presentation pathways in various contexts, ranging from model antigens in non-infectious settings to pathogen-infected cells. We suggest that presentation of intracellular pathogens can be described as not just one, but several distinct pathways; perhaps because diverse pathogens have evolved different strategies to interact with host cells.
AB - Within cells of their host, many bacteria and parasites inhabit specialized compartments, such as a modified phagosome for Mycobacterium tuberculosis or a parasitophorous vacuole for Toxoplasma gondii. These locations could exclude microbial material from entry into the MHC class I surveillance pathway. Remarkably, however, under these circumstances, cells can still signal the presence of invading pathogens to circulating CD8+ T cells, which typically play a key role in protection against such intracellular organisms. Here, we review MHC I presentation pathways in various contexts, ranging from model antigens in non-infectious settings to pathogen-infected cells. We suggest that presentation of intracellular pathogens can be described as not just one, but several distinct pathways; perhaps because diverse pathogens have evolved different strategies to interact with host cells.
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U2 - 10.1016/j.it.2010.08.004
DO - 10.1016/j.it.2010.08.004
M3 - Review article
C2 - 20869317
AN - SCOPUS:78049287610
SN - 1471-4906
VL - 31
SP - 414
EP - 421
JO - Trends in Immunology
JF - Trends in Immunology
IS - 11
ER -