Topological journey of parasite-derived antigens for presentation by MHC class I molecules

Nicolas Blanchard, Nilabh Shastri

Research output: Contribution to journalReview article

Abstract

Within cells of their host, many bacteria and parasites inhabit specialized compartments, such as a modified phagosome for Mycobacterium tuberculosis or a parasitophorous vacuole for Toxoplasma gondii. These locations could exclude microbial material from entry into the MHC class I surveillance pathway. Remarkably, however, under these circumstances, cells can still signal the presence of invading pathogens to circulating CD8+ T cells, which typically play a key role in protection against such intracellular organisms. Here, we review MHC I presentation pathways in various contexts, ranging from model antigens in non-infectious settings to pathogen-infected cells. We suggest that presentation of intracellular pathogens can be described as not just one, but several distinct pathways; perhaps because diverse pathogens have evolved different strategies to interact with host cells.

Original languageEnglish (US)
Pages (from-to)414-421
Number of pages8
JournalTrends in Immunology
Volume31
Issue number11
DOIs
StatePublished - Nov 1 2010

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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