Abstract
Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Annette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 226-231 |
| Number of pages | 6 |
| Journal | Parasitology Today |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1996 |
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ASJC Scopus subject areas
- Parasitology
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Topoisomerases in kinetoplastids. / Burri, Christian; Bodley, Annette L.; Shapiro, Theresa A.
In: Parasitology Today, Vol. 12, No. 6, 06.1996, p. 226-231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Topoisomerases in kinetoplastids
AU - Burri, Christian
AU - Bodley, Annette L.
AU - Shapiro, Theresa A
PY - 1996/6
Y1 - 1996/6
N2 - Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Annette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets.
AB - Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Annette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets.
UR - http://www.scopus.com/inward/record.url?scp=0029890112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029890112&partnerID=8YFLogxK
U2 - 10.1016/0169-4758(96)10017-X
DO - 10.1016/0169-4758(96)10017-X
M3 - Article
C2 - 15275202
AN - SCOPUS:0029890112
VL - 12
SP - 226
EP - 231
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 6
ER -