TY - JOUR
T1 - Topoisomerases in kinetoplastids
AU - Burri, Christian
AU - Bodley, Annette L.
AU - Shapiro, Theresa A.
N1 - Funding Information:
We thank Paul Englund and Donna Klinedinst for reading this manuscript. Work in our laboratory was supported by US Public Health Service grant AI-28855, by a Scholar Award in Experimental Therapeutics from the Burroughs Wellcome Fund (TS), by the Swiss National Research Foundation (CB). the Ciba Jubilaeums Foundation (CB). and the Theodor Engelmann Foundation (CB),
PY - 1996/6
Y1 - 1996/6
N2 - Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Annette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets.
AB - Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Annette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets.
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U2 - 10.1016/0169-4758(96)10017-X
DO - 10.1016/0169-4758(96)10017-X
M3 - Review article
C2 - 15275202
AN - SCOPUS:0029890112
VL - 12
SP - 226
EP - 231
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 6
ER -