Topographic, non-collateralized basal forebrain projections to amygdala, hippocampus, and anterior cingulate cortex in the rhesus monkey

Vassilis E. Koliatsos, Lee J. Martin, Lary C. Walker, Russell T. Richardson, Mahlon R. DeLong, Donald L. Price

Research output: Contribution to journalArticlepeer-review

Abstract

Projections of the basal forebrain magnocellular complex to the limbic telencephalon of the primate were studied by combining double-retrograde tracing with immunocytochemistry. Tracers were injected into anterior cingulate cortex and hippocampus or into hippocampus and amygdala. Retrogradely labeled populations of neurons were topographically arranged but intermingled peripherally. Double-labeled neurons, found only after amygdala-hippocampus injections, were very rare. Approximately 30% of hippocampopetal, 50-70% of amygdalopetal, and 50-90% of cingulopetal neurons were cholinergic; percentages varied among different regions of basal forebrain. These findings further support the concept of a system with a highly organized efferent circuitry.

Original languageEnglish (US)
Pages (from-to)133-139
Number of pages7
JournalBrain research
Volume463
Issue number1
DOIs
StatePublished - Oct 25 1988

Keywords

  • Cholinergic pathway
  • Diagonal band
  • Limbic system
  • Medial septum
  • Nucleus basalis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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