Topical tretinoin (retinoic acid) improves early stretch marks

Sewon Kang, Kwang J. Kim, Christopher E M Griffiths, Tai Yuen Wong, Harvinder S. Talwar, Gary J. Fisher, David Gordon, Ted A. Hamilton, Charles N. Ellis, John J. Voorhees

Research output: Contribution to journalArticle

Abstract

Background and Design: Stretch marks are disfiguring lesions usually caused by excessive stretching of skin. We investigated the response of early, clinically active stretch marks to topical 0.1% tretinoin (retinoic acid) cream. In a double-blind, randomized, vehicle-controlled study, 22 patients applied either 0.1% tretinoin (n=10) or vehicle (n=12) daily for 6 months to the affected areas. Patients were evaluated by physical examination monthly and by analysis of biopsy specimens of stretch marks obtained before and at the end of therapy in comparison with untreated normal skin. Results: After 2 months, patients treated with tretinoin had significant improvement in severity scores of stretch marks compared with patients who received vehicle (P

Original languageEnglish (US)
Pages (from-to)519-526
Number of pages8
JournalArchives of Dermatology
Volume132
Issue number5
DOIs
StatePublished - May 1996
Externally publishedYes

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Striae Distensae
Tretinoin
Skin
Physical Examination
Biopsy

ASJC Scopus subject areas

  • Dermatology

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Kang, S., Kim, K. J., Griffiths, C. E. M., Wong, T. Y., Talwar, H. S., Fisher, G. J., ... Voorhees, J. J. (1996). Topical tretinoin (retinoic acid) improves early stretch marks. Archives of Dermatology, 132(5), 519-526. https://doi.org/10.1001/archderm.132.5.519

Topical tretinoin (retinoic acid) improves early stretch marks. / Kang, Sewon; Kim, Kwang J.; Griffiths, Christopher E M; Wong, Tai Yuen; Talwar, Harvinder S.; Fisher, Gary J.; Gordon, David; Hamilton, Ted A.; Ellis, Charles N.; Voorhees, John J.

In: Archives of Dermatology, Vol. 132, No. 5, 05.1996, p. 519-526.

Research output: Contribution to journalArticle

Kang, S, Kim, KJ, Griffiths, CEM, Wong, TY, Talwar, HS, Fisher, GJ, Gordon, D, Hamilton, TA, Ellis, CN & Voorhees, JJ 1996, 'Topical tretinoin (retinoic acid) improves early stretch marks', Archives of Dermatology, vol. 132, no. 5, pp. 519-526. https://doi.org/10.1001/archderm.132.5.519
Kang S, Kim KJ, Griffiths CEM, Wong TY, Talwar HS, Fisher GJ et al. Topical tretinoin (retinoic acid) improves early stretch marks. Archives of Dermatology. 1996 May;132(5):519-526. https://doi.org/10.1001/archderm.132.5.519
Kang, Sewon ; Kim, Kwang J. ; Griffiths, Christopher E M ; Wong, Tai Yuen ; Talwar, Harvinder S. ; Fisher, Gary J. ; Gordon, David ; Hamilton, Ted A. ; Ellis, Charles N. ; Voorhees, John J. / Topical tretinoin (retinoic acid) improves early stretch marks. In: Archives of Dermatology. 1996 ; Vol. 132, No. 5. pp. 519-526.
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