Topical tissue factor pathway inhibitor improves free-flap survival in a model simulating free-flap errors

M. R. Ozbeck, D. M. Brown, E Gene Deune, L. A. Lantieri, N. M. Kania, E. N. Pasia, B. C. Cooley, T. C. Wun, R. K. Khouri

Research output: Contribution to journalArticle

Abstract

Free flap failure is frequently due to tension, twisting, kinking, or compression of the vascular pedicle after the anastomosis is completed A rabbit model simulating these errors was used to evaluate the capacity of topically-applied tissue factor pathway inhibitor (TFPI) to prevent microvascular thrombosis. The rabbit ear was isolated on the central artery and vein the artery was transected, shortened, repaired, and twisted 360° around the vein immediately following the anastomosis, TFPI in concentrations of 1, 4, 10, or 40 μg/ml was irrigated across the lumen. Topically-applied control buffer and heparin (50 U/ml) were compared to TFPI. Treatment with control buffer resulted in a 20 percent survival rate topically-applied heparin improved the survival rate to 60 percent (p

Original languageEnglish (US)
Pages (from-to)185-188
Number of pages4
JournalJournal of Reconstructive Microsurgery
Volume11
Issue number3
StatePublished - 1995
Externally publishedYes

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Free Tissue Flaps
Heparin
Veins
Buffers
Arteries
Rabbits
Ear
Blood Vessels
Thrombosis
lipoprotein-associated coagulation inhibitor

ASJC Scopus subject areas

  • Surgery

Cite this

Ozbeck, M. R., Brown, D. M., Deune, E. G., Lantieri, L. A., Kania, N. M., Pasia, E. N., ... Khouri, R. K. (1995). Topical tissue factor pathway inhibitor improves free-flap survival in a model simulating free-flap errors. Journal of Reconstructive Microsurgery, 11(3), 185-188.

Topical tissue factor pathway inhibitor improves free-flap survival in a model simulating free-flap errors. / Ozbeck, M. R.; Brown, D. M.; Deune, E Gene; Lantieri, L. A.; Kania, N. M.; Pasia, E. N.; Cooley, B. C.; Wun, T. C.; Khouri, R. K.

In: Journal of Reconstructive Microsurgery, Vol. 11, No. 3, 1995, p. 185-188.

Research output: Contribution to journalArticle

Ozbeck, MR, Brown, DM, Deune, EG, Lantieri, LA, Kania, NM, Pasia, EN, Cooley, BC, Wun, TC & Khouri, RK 1995, 'Topical tissue factor pathway inhibitor improves free-flap survival in a model simulating free-flap errors', Journal of Reconstructive Microsurgery, vol. 11, no. 3, pp. 185-188.
Ozbeck, M. R. ; Brown, D. M. ; Deune, E Gene ; Lantieri, L. A. ; Kania, N. M. ; Pasia, E. N. ; Cooley, B. C. ; Wun, T. C. ; Khouri, R. K. / Topical tissue factor pathway inhibitor improves free-flap survival in a model simulating free-flap errors. In: Journal of Reconstructive Microsurgery. 1995 ; Vol. 11, No. 3. pp. 185-188.
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AU - Kania, N. M.

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