Topical retinoid treatment for various dry-eye disorders

S. C G Tseng, A. E. Maumenee, W. J. Stark, A. D. Jensen, Allan D. Jensen, K. R. Kenyon

Research output: Contribution to journalArticle

Abstract

We evaluated the clinical efficacy of treating various dry-eye disorders using 0.01% and 0.1% (weight/weight) topical all-trans retinoic acid ointment. Twenty-two patients were selected and classified into 4 major groups: (1) keratoconjunctivitis sicca (6 patients; 11 eyes), (2) Stevens-Johnson syndrome (9 patients; 17 eyes), (3) ocular pemphigoid or drug-induced pseudopemphigoid (3 patients; 6 eyes), and (4) surgery or radiation-induced dry eye (4 patients; 4 eyes), based on the criterion that they remained symptomatic even under maximum tolerable conventional medical and/or surgical therapies. The results indicated that squamous metaplasia with mucin deficiency secondary to goblet cell loss and keratinization may be the basis for the development of clinical symptoms and morbidities, as these epithelial abnormalities were invariably present before treatment. After treatment, all patients demonstrated clinical improvements in symptoms, visual acuity, rose Bengal staining, or Schirmer test. Most importantly, this topical vitamin A treatment caused the reversal of squamous metaplasia as evidenced by impression cytology. Therefore, this treatment may represent the first nonsurgical attempt to treat these disorders by reversing diseased ocular surface epithelium.

Original languageEnglish (US)
Pages (from-to)717-727
Number of pages11
JournalOphthalmology
Volume92
Issue number6
StatePublished - 1985

Fingerprint

Retinoids
Metaplasia
Therapeutics
Keratoconjunctivitis Sicca
Rose Bengal
Weights and Measures
Bullous Pemphigoid
Stevens-Johnson Syndrome
Goblet Cells
Mucins
Ointments
Tretinoin
Vitamin A
Visual Acuity
Cell Biology
Epithelium
Radiation
Staining and Labeling
Morbidity
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tseng, S. C. G., Maumenee, A. E., Stark, W. J., Jensen, A. D., Jensen, A. D., & Kenyon, K. R. (1985). Topical retinoid treatment for various dry-eye disorders. Ophthalmology, 92(6), 717-727.

Topical retinoid treatment for various dry-eye disorders. / Tseng, S. C G; Maumenee, A. E.; Stark, W. J.; Jensen, A. D.; Jensen, Allan D.; Kenyon, K. R.

In: Ophthalmology, Vol. 92, No. 6, 1985, p. 717-727.

Research output: Contribution to journalArticle

Tseng, SCG, Maumenee, AE, Stark, WJ, Jensen, AD, Jensen, AD & Kenyon, KR 1985, 'Topical retinoid treatment for various dry-eye disorders', Ophthalmology, vol. 92, no. 6, pp. 717-727.
Tseng SCG, Maumenee AE, Stark WJ, Jensen AD, Jensen AD, Kenyon KR. Topical retinoid treatment for various dry-eye disorders. Ophthalmology. 1985;92(6):717-727.
Tseng, S. C G ; Maumenee, A. E. ; Stark, W. J. ; Jensen, A. D. ; Jensen, Allan D. ; Kenyon, K. R. / Topical retinoid treatment for various dry-eye disorders. In: Ophthalmology. 1985 ; Vol. 92, No. 6. pp. 717-727.
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