TY - JOUR
T1 - Topical Microbicides in HIV Prevention
T2 - State of the Promise
AU - Baeten, Jared M.
AU - Hendrix, Craig W.
AU - Hillier, Sharon L.
N1 - Publisher Copyright:
© 2020 by Annual Reviews. All rights reserved.
PY - 2020/1/27
Y1 - 2020/1/27
N2 - HIV topical microbicides are products with anti-HIV activity, generally incorporating a direct-Acting antiretroviral agent, that when applied to the vagina or rectum have the potential to prevent the sexual acquisition of HIV in women and men. Topical microbicides may meet the prevention needs of individuals and groups for whom oral daily forms of pre-exposure prophylaxis (PrEP) have not been acceptable. Microbicides can provide personal control over HIV prevention and offer the possibility of discreet use, qualities that may be particularly important for receptive partners in sexual relationships such as women and transgender women and men, who together account for the clear majority of new HIV infections worldwide. Although the promise of such a product emerged nearly three decades ago, proof of concept has been demonstrated only within the last decade. A robust pipeline of microbicidal gels, films, inserts, and rings has been evaluated in multiple studies among at-risk women and men, and refinement of products for ease of use, reversibility, and high safety is the priority for the field.
AB - HIV topical microbicides are products with anti-HIV activity, generally incorporating a direct-Acting antiretroviral agent, that when applied to the vagina or rectum have the potential to prevent the sexual acquisition of HIV in women and men. Topical microbicides may meet the prevention needs of individuals and groups for whom oral daily forms of pre-exposure prophylaxis (PrEP) have not been acceptable. Microbicides can provide personal control over HIV prevention and offer the possibility of discreet use, qualities that may be particularly important for receptive partners in sexual relationships such as women and transgender women and men, who together account for the clear majority of new HIV infections worldwide. Although the promise of such a product emerged nearly three decades ago, proof of concept has been demonstrated only within the last decade. A robust pipeline of microbicidal gels, films, inserts, and rings has been evaluated in multiple studies among at-risk women and men, and refinement of products for ease of use, reversibility, and high safety is the priority for the field.
KW - HIV
KW - HIV prevention
KW - dapivirine vaginal ring
KW - microbicide
UR - http://www.scopus.com/inward/record.url?scp=85078570400&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078570400&partnerID=8YFLogxK
U2 - 10.1146/annurev-med-090518-093731
DO - 10.1146/annurev-med-090518-093731
M3 - Review article
C2 - 31613684
AN - SCOPUS:85078570400
SN - 0066-4219
VL - 71
SP - 361
EP - 377
JO - Annual review of medicine
JF - Annual review of medicine
ER -