Topical difluprednate for the treatment of retinal vasculitis associated with birdshot chorioretinitis

Purpose To report a case of retinal vasculitis associated with birdshot chorioretinitis which was responsive to topical difluprednate alone. Observations Two months after initiation of topical difluprednate, fluorescein angiography demonstrated resolution of retinal vasculitis in both treated eyes. Worsening of vasculitis with attempted taper of difluprednate and subsequent control with prior dosing confirmed the response. Conclusions and importance Despite potential adverse effects of steroid-induced glaucoma and cataract formation, topical difluprednate in the treatment of retinal vasculitis and other posterior uveitides may have efficacy.