Topical Chemotherapy and Immunotherapy of Mycosis Fungoides: Intermediate-Term Results

Eric C. Vonderheid; Eugene J. Van Scott; Waine C. Johnson; David A. Grekin; Sucha O. Asbell

doi:10.1001/archderm.1977.01640040062009

Topical Chemotherapy and Immunotherapy of Mycosis Fungoides: Intermediate-Term Results

Eric C. Vonderheid, Eugene J. Van Scott, Waine C. Johnson, David A. Grekin, Sucha O. Asbell

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

A group of 220 patients with mycosis fungoides (MF) and other lymphomatous diseases was treated with sustained topical applications of dilute aqueous solutions of mechlorethamine hydrochloride for intervals ranging in excess of seven years. Response to treatment, immunologic responsiveness, and subsequent course and survival were inversely related to magnitude of disease at time of starting treatment. Relapses were common, and in most instances were related to failure of maintenance of topical therapy rather than to drug resistance. In selected patients topical therapy with an analog of mechlorethamine (nor-mechlorethamine) and with topical immunogenic agents provided additional improvement.

Original language	English (US)
Pages (from-to)	454-462
Number of pages	9
Journal	Archives of Dermatology
Volume	113
Issue number	4
DOIs	https://doi.org/10.1001/archderm.1977.01640040062009
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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10.1001/archderm.1977.01640040062009

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abstract = "A group of 220 patients with mycosis fungoides (MF) and other lymphomatous diseases was treated with sustained topical applications of dilute aqueous solutions of mechlorethamine hydrochloride for intervals ranging in excess of seven years. Response to treatment, immunologic responsiveness, and subsequent course and survival were inversely related to magnitude of disease at time of starting treatment. Relapses were common, and in most instances were related to failure of maintenance of topical therapy rather than to drug resistance. In selected patients topical therapy with an analog of mechlorethamine (nor-mechlorethamine) and with topical immunogenic agents provided additional improvement.",

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AU - Grekin, David A.

AU - Asbell, Sucha O.

PY - 1977

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AB - A group of 220 patients with mycosis fungoides (MF) and other lymphomatous diseases was treated with sustained topical applications of dilute aqueous solutions of mechlorethamine hydrochloride for intervals ranging in excess of seven years. Response to treatment, immunologic responsiveness, and subsequent course and survival were inversely related to magnitude of disease at time of starting treatment. Relapses were common, and in most instances were related to failure of maintenance of topical therapy rather than to drug resistance. In selected patients topical therapy with an analog of mechlorethamine (nor-mechlorethamine) and with topical immunogenic agents provided additional improvement.

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Topical Chemotherapy and Immunotherapy of Mycosis Fungoides: Intermediate-Term Results

Abstract

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