TY - JOUR
T1 - Topical calcipotriene has no short-term effect on calcium and bone metabolism of patients with psoriasis
AU - Guzzo, Cynthia
AU - Lazarus, Gerald
AU - Goffe, Bernard S.
AU - Katz, H. Irving
AU - Lowe, Nicholas J.
AU - Pincus, Stephanie H.
N1 - Funding Information:
From the University of Pennsylvania, Department of Dermatology, Philadelphiaa; the Psoriasis Treatment Center, Seattleb; Minnesota Clinical Study Center, FridleyC; Skin Research Fonndation of Cal-ifornia, Santa Monicad; and the State University of New York, De-pamnent of Dermatology, Buffalo. e Supported by Bristol Myers Squibb Company. Accepted for publication Aug. 15, 1995. Reprint requests: Cynthia Guzzo, MD, Hospital of the University of Pennsylvania, Deparmaent of Dermatology, 2 Maloney Building, 3600 Spruce St., Philadelphia, PA 19104-4211. Copyright © 1996 by the American Academy of Dermatology, Inc. 0190-9622/96 $5.00 + 0 16/1/68612
PY - 1996/3
Y1 - 1996/3
N2 - Background: The biologically active form of vitamin D3, calcitriol, is effective in the treatment of psoriasis but can alter calcium metabolism. Calcipotriene is an analog of calcitriol that has low calcemic activity and aids in clearing psoriasis. Objective: The purpose of this study was to determine the safety of topical therapy with calcipotriene particularly in relation to calcium and bone metabolism. Methods: In a double-blind, randomized, parallel, vehicle-controlled trial, 78 adults with plaque psoriasis were treated twice daily with topical calcipotriene ointment (50 μg/gm, maximum usage, 120 gm per week) or vehicle for 8 weeks. After a screening visit, patients were admitted to the hospital at weeks 0 (baseline), 1, 2, 4, and 8. Blood and urine chemistry analysis included parathyroid hormone, serum calcium, bone-specific alkaline phosphatase, urinary hydroxyproline, and 24 hour urinary calcium excretion. Bone densitometry measures were performed at baseline and week 8. Results: No incidences of calcipotriene treatment-related hypercalcemia, calcium mobilization from bone, or clinically significant changes in bone density were noted during this study. Conclusion: Topical application of up to 120 gm per week of calcipotriene ointment for 8 weeks is safe and effective for plaque psoriasis. There were no adverse effects on calcium and bone metabolism during this 8-week study.
AB - Background: The biologically active form of vitamin D3, calcitriol, is effective in the treatment of psoriasis but can alter calcium metabolism. Calcipotriene is an analog of calcitriol that has low calcemic activity and aids in clearing psoriasis. Objective: The purpose of this study was to determine the safety of topical therapy with calcipotriene particularly in relation to calcium and bone metabolism. Methods: In a double-blind, randomized, parallel, vehicle-controlled trial, 78 adults with plaque psoriasis were treated twice daily with topical calcipotriene ointment (50 μg/gm, maximum usage, 120 gm per week) or vehicle for 8 weeks. After a screening visit, patients were admitted to the hospital at weeks 0 (baseline), 1, 2, 4, and 8. Blood and urine chemistry analysis included parathyroid hormone, serum calcium, bone-specific alkaline phosphatase, urinary hydroxyproline, and 24 hour urinary calcium excretion. Bone densitometry measures were performed at baseline and week 8. Results: No incidences of calcipotriene treatment-related hypercalcemia, calcium mobilization from bone, or clinically significant changes in bone density were noted during this study. Conclusion: Topical application of up to 120 gm per week of calcipotriene ointment for 8 weeks is safe and effective for plaque psoriasis. There were no adverse effects on calcium and bone metabolism during this 8-week study.
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U2 - 10.1016/S0190-9622(96)90434-X
DO - 10.1016/S0190-9622(96)90434-X
M3 - Article
C2 - 8609254
AN - SCOPUS:0029880462
SN - 0190-9622
VL - 34
SP - 429
EP - 433
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 3
ER -