Topical Anesthesia With EMLA Reduces Pain During Endomyocardial Biopsy: a Randomized Trial

Dianne H. Leloudis, Michelle M. Kittleson, G. Michael Felker, Paul B. Rosenberg, Adrian F. Hernandez, Jonathan E. Yager, Stuart D. Russell

Research output: Contribution to journalArticle

Abstract

Cardiac transplant recipients often anticipate and suffer varying degrees of discomfort during surveillance endomyocardial biopsy (EMBx). We performed a randomized, blinded, placebo-controlled trial to determine whether topical anesthetic was associated with reduced pain and to identify factors associated with increased pain perception during EMBx. In 225 EMBxs, use of the eutectic mixture of lidocaine and prilocaine (EMLA) decreased pain score (-7.3 compared with placebo; p = 0.04); the other significant predictors of increased pain scores were time to achieve access (+2.3 per minute; p = 0.001) and female gender (+12.7 compared with males; p = 0.003). Topical anesthetic cream is associated with decreased pain during EMBx, even after adjusting for other predictors of pain, including female gender and longer time to achieve access. A better understanding of the factors affecting pain during EMBx could improve the comfort level of this procedure.

Original languageEnglish (US)
Pages (from-to)1164-1166
Number of pages3
JournalJournal of Heart and Lung Transplantation
Volume25
Issue number9
DOIs
StatePublished - Sep 2006

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Anesthesia
Biopsy
Pain
Local Anesthetics
Placebos
Pain Perception
EMLA

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Leloudis, D. H., Kittleson, M. M., Felker, G. M., Rosenberg, P. B., Hernandez, A. F., Yager, J. E., & Russell, S. D. (2006). Topical Anesthesia With EMLA Reduces Pain During Endomyocardial Biopsy: a Randomized Trial. Journal of Heart and Lung Transplantation, 25(9), 1164-1166. https://doi.org/10.1016/j.healun.2006.06.016

Topical Anesthesia With EMLA Reduces Pain During Endomyocardial Biopsy : a Randomized Trial. / Leloudis, Dianne H.; Kittleson, Michelle M.; Felker, G. Michael; Rosenberg, Paul B.; Hernandez, Adrian F.; Yager, Jonathan E.; Russell, Stuart D.

In: Journal of Heart and Lung Transplantation, Vol. 25, No. 9, 09.2006, p. 1164-1166.

Research output: Contribution to journalArticle

Leloudis, DH, Kittleson, MM, Felker, GM, Rosenberg, PB, Hernandez, AF, Yager, JE & Russell, SD 2006, 'Topical Anesthesia With EMLA Reduces Pain During Endomyocardial Biopsy: a Randomized Trial', Journal of Heart and Lung Transplantation, vol. 25, no. 9, pp. 1164-1166. https://doi.org/10.1016/j.healun.2006.06.016
Leloudis, Dianne H. ; Kittleson, Michelle M. ; Felker, G. Michael ; Rosenberg, Paul B. ; Hernandez, Adrian F. ; Yager, Jonathan E. ; Russell, Stuart D. / Topical Anesthesia With EMLA Reduces Pain During Endomyocardial Biopsy : a Randomized Trial. In: Journal of Heart and Lung Transplantation. 2006 ; Vol. 25, No. 9. pp. 1164-1166.
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