Tools for cell signaling: Synthesis of the 3-phosphatase-resistant 1,3,4,5-InsP4 mimic, 1D-myo-inositol 1,4,5-trisphosphate 3-phosphorothioate

Alan P. Kozikowski, Abdul H. Fauq, Robert A. Wilcox, Stefan R. Nahorski

Research output: Contribution to journalArticle

Abstract

The synthesis of 1D-myo-inositol 1,4,5-trisphosphate 3-phosphorothioate, a 3-phosphatase-resistant analogue of 1,3,4,5-InsP4 is reported, and this compound is shown to elicit 45Ca2+ release with an EC50 which is comparable to that of the natural metabolite, thus supporting the idea that 1,3,4,5-InsP4 can interact with the 1,4,5-InsP3 receptors.

Original languageEnglish (US)
Pages (from-to)2279-2281
Number of pages3
JournalJournal of Organic Chemistry
Volume59
Issue number9
StatePublished - 1994
Externally publishedYes

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Cell signaling
Inositol 1,4,5-Trisphosphate
Phosphoric Monoester Hydrolases
Metabolites

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Tools for cell signaling : Synthesis of the 3-phosphatase-resistant 1,3,4,5-InsP4 mimic, 1D-myo-inositol 1,4,5-trisphosphate 3-phosphorothioate. / Kozikowski, Alan P.; Fauq, Abdul H.; Wilcox, Robert A.; Nahorski, Stefan R.

In: Journal of Organic Chemistry, Vol. 59, No. 9, 1994, p. 2279-2281.

Research output: Contribution to journalArticle

Kozikowski, Alan P. ; Fauq, Abdul H. ; Wilcox, Robert A. ; Nahorski, Stefan R. / Tools for cell signaling : Synthesis of the 3-phosphatase-resistant 1,3,4,5-InsP4 mimic, 1D-myo-inositol 1,4,5-trisphosphate 3-phosphorothioate. In: Journal of Organic Chemistry. 1994 ; Vol. 59, No. 9. pp. 2279-2281.
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