Tools for Cell Signaling: Synthesis of the 3-Phosphatase-Resistant 1,3,4,5-InsP4 Mimic, 1D-myo-Inositol 1,4,5-Trisphosphate 3-Phosphorothioate

Alan P. Kozikowski, Abdul H. Fauq, Robert A. Wilcox, Stefan R. Nahorski

Research output: Contribution to journalArticle

Abstract

The synthesis of 1D-myo-inositol 1,4,5- trisphosphate 3-phosphorothioate, a 3-phosphataseresistant analogue of 1,3,4,5-InsP4 is reported, and this compound is shown to elicit 45Ca2+ release with an EC50 which is comparable to that of the natural metabolite, thus supporting the idea that 1,3,4,5-InsP4 can interact with the 1,4,5-InsP3 receptors.

Original languageEnglish (US)
Pages (from-to)2279-2281
Number of pages3
JournalJournal of Organic Chemistry
Volume59
Issue number9
DOIs
StatePublished - May 1 1994

ASJC Scopus subject areas

  • Organic Chemistry

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