Abstract
Processes of vestibular compensation mediate recovery of many aspects of vestibular dysfunction following unilateral vestibular injury. The VOR in response to high-frequency, high-acceleration head movements, however, retains an enduring asymmetry. Head movements that are inhibitory with respect to semicircular canals on the intact side lead to a diminished VOR whereas head movements that are excitatory for semicircular canals on the intact side lead to a VOR that returns close to normal. We review our work directed toward understanding the processes of VOR compensation to high-frequency, high-acceleration head movements and the related topic of adaptation to changes in the visual requirements for a compensatory VOR. Our work has shown that the processes of both compensation and adaptation to these stimuli can be described by a mathematical model with inputs from tonic and phasic components. We have further shown that the dynamics of regular afferents have close resemblance to the tonic pathway whereas the dynamics of irregular afferents match those of the phasic pathway.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-170 |
| Number of pages | 12 |
| Journal | Journal of Vestibular Research: Equilibrium and Orientation |
| Volume | 19 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - 2009 |
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Keywords
- high acceleration head movement
- irregular afferent
- labyrinthectomy
- mathematical model
- Regular afferent
- retinal slip error
- semicircular canals
- vestibular
- vestibular hypofunction
ASJC Scopus subject areas
- Otorhinolaryngology
- Clinical Neurology
- Sensory Systems
- Neuroscience(all)
Cite this
Tonic and phasic contributions to the pathways mediating compensation and adaptation of the vestibulo-ocular reflex. / Minor, Lloyd B.; Lasker, David M.
In: Journal of Vestibular Research: Equilibrium and Orientation, Vol. 19, No. 5-6, 2009, p. 159-170.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tonic and phasic contributions to the pathways mediating compensation and adaptation of the vestibulo-ocular reflex
AU - Minor, Lloyd B.
AU - Lasker, David M.
PY - 2009
Y1 - 2009
N2 - Processes of vestibular compensation mediate recovery of many aspects of vestibular dysfunction following unilateral vestibular injury. The VOR in response to high-frequency, high-acceleration head movements, however, retains an enduring asymmetry. Head movements that are inhibitory with respect to semicircular canals on the intact side lead to a diminished VOR whereas head movements that are excitatory for semicircular canals on the intact side lead to a VOR that returns close to normal. We review our work directed toward understanding the processes of VOR compensation to high-frequency, high-acceleration head movements and the related topic of adaptation to changes in the visual requirements for a compensatory VOR. Our work has shown that the processes of both compensation and adaptation to these stimuli can be described by a mathematical model with inputs from tonic and phasic components. We have further shown that the dynamics of regular afferents have close resemblance to the tonic pathway whereas the dynamics of irregular afferents match those of the phasic pathway.
AB - Processes of vestibular compensation mediate recovery of many aspects of vestibular dysfunction following unilateral vestibular injury. The VOR in response to high-frequency, high-acceleration head movements, however, retains an enduring asymmetry. Head movements that are inhibitory with respect to semicircular canals on the intact side lead to a diminished VOR whereas head movements that are excitatory for semicircular canals on the intact side lead to a VOR that returns close to normal. We review our work directed toward understanding the processes of VOR compensation to high-frequency, high-acceleration head movements and the related topic of adaptation to changes in the visual requirements for a compensatory VOR. Our work has shown that the processes of both compensation and adaptation to these stimuli can be described by a mathematical model with inputs from tonic and phasic components. We have further shown that the dynamics of regular afferents have close resemblance to the tonic pathway whereas the dynamics of irregular afferents match those of the phasic pathway.
KW - high acceleration head movement
KW - irregular afferent
KW - labyrinthectomy
KW - mathematical model
KW - Regular afferent
KW - retinal slip error
KW - semicircular canals
KW - vestibular
KW - vestibular hypofunction
UR - http://www.scopus.com/inward/record.url?scp=77953776649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953776649&partnerID=8YFLogxK
U2 - 10.3233/VES-2009-0353
DO - 10.3233/VES-2009-0353
M3 - Article
C2 - 20495233
AN - SCOPUS:77953776649
VL - 19
SP - 159
EP - 170
JO - Journal of Vestibular Research: Equilibrium and Orientation
JF - Journal of Vestibular Research: Equilibrium and Orientation
SN - 0957-4271
IS - 5-6
ER -