Tomosynthesis-based radioactive seed localization in prostate brachytherapy using modified distance map images

Junghoon Lee, Xiaofeng Liu, Ameet K. Jain, Jerry L. Prince, Gabor Fichtinger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a tomosynthesis-based radioactive seed localization method for prostate brachytherapy. In contrast to the projection image-based matching approach, our method does not involve explicit segmentation of seeds and can recover hidden seeds. Modified distance map images are computed from a limited number of x-ray projection images, and are backprojected to reconstuct a 3-D volume of interest. Candidate seed locations are extracted from the reconstructed volume and false positive seeds are eliminated by solving an optimal geometry coverage problem. The simulation results indicate that the implanted seed locations can be estimated from three or four images depending on the number of seeds if the pose of a C-arm is known. The algorithm was validated using phantom and clinical patient data.

Original languageEnglish (US)
Title of host publication2008 5th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, Proceedings, ISBI
Pages680-683
Number of pages4
DOIs
StatePublished - 2008
Event2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI - Paris, France
Duration: May 14 2008May 17 2008

Publication series

Name2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI

Other

Other2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI
Country/TerritoryFrance
CityParis
Period5/14/085/17/08

Keywords

  • Brachytherapy
  • Modified distance map
  • Prostate cancer
  • Tomosynthesis

ASJC Scopus subject areas

  • Biomedical Engineering

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