Toll-like receptors: roles in neuroprotection?

Uwe Karsten Hanisch, Thomas V. Johnson, Jonathan Kipnis

Research output: Contribution to journalArticlepeer-review

Abstract

Toll-like receptors (TLRs) enable mammalian cells to sense pathogenic challenges. They are essential for appropriate initiation, execution and regulation of innate and adaptive immune responses. Whereas TLR-mediated processes in the central nervous system (CNS) might contribute to detrimental (auto)immune reactions, they are unlikely to have exclusively neurodestructive consequences. Indeed, appropriately controlled TLR signaling might be crucial for preserving CNS structure and function in certain contexts. Recent findings illustrate neuroprotective capacities for TLRs, mediated by containment of trauma-associated infection or by recruitment of neuroprotective T lymphocytes. By the latter mechanism, endogenous or therapeutically administered TLR ligands could conceivably generate neuroprotective benefits in noninfectious CNS disorders. This article focuses on the yet less-addressed protective potential of TLR engagement within the CNS.

Original languageEnglish (US)
Pages (from-to)176-182
Number of pages7
JournalTrends in Neurosciences
Volume31
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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