Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury

Yue Wang, Aaron M. Abarbanell, Jeremy L. Herrmann, Brent R. Weil, Jeffrey Poynter, Mariuxi C. Manukyan, Paul R. Crisostomo, Daniel R. Meldrum

Research output: Contribution to journalReview article

Abstract

Toll-like receptors (TLRs) play a key role in innate immune defenses. After activation by foreign pathogens or host-derived molecules, TLRs signal via overlapping or distinct signaling cascades and eventually induce numerous genes involved in a variety of cellular responses. A growing body of evidence suggests that TLR signaling also plays an important role in cardiac ischemia/reperfusion injury. We review our current understanding of the TLR signaling pathways and their roles in the pathophysiology of cardiac ischemia/reperfusion injury, as well as discuss several mechanisms for TLR activation and regulation.

Original languageEnglish (US)
Pages (from-to)548-557
Number of pages10
JournalShock
Volume34
Issue number6
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Keywords

  • Toll-like receptor
  • ischemia/reperfusion injury
  • signaling pathways

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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  • Cite this

    Wang, Y., Abarbanell, A. M., Herrmann, J. L., Weil, B. R., Poynter, J., Manukyan, M. C., Crisostomo, P. R., & Meldrum, D. R. (2010). Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury. Shock, 34(6), 548-557. https://doi.org/10.1097/SHK.0b013e3181e686f5