Toll-like receptor signaling in neural plasticity and disease

Eitan Okun, Kathleen J. Griffioen, Mark P. Mattson

Research output: Contribution to journalArticle

Abstract

Toll-like receptors (TLRs) are a family of innate immune system receptors that respond to pathogen-derived and tissue damage-related ligands. TLR signaling in immune cells, glia and neurons can play roles in the pathogenesis of stroke, Alzheimer's disease (AD) and multiple sclerosis (MS). Recent findings suggest that TLR signaling also influences multiple dynamic processes in the developing and adult central nervous system including neurogenesis, axonal growth and structural plasticity. In addition, TLRs are implicated in the regulation of behaviors including learning, memory and anxiety. This review describes recently discovered and unexpected roles for TLRs in neuroplasticity, and the implications of these findings for future basic and translational research studies.

Original languageEnglish (US)
Pages (from-to)269-281
Number of pages13
JournalTrends in Neurosciences
Volume34
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

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Neuronal Plasticity
Toll-Like Receptors
Alzheimer Disease
Translational Medical Research
Neurogenesis
Neuroglia
Multiple Sclerosis
Immune System
Anxiety
Central Nervous System
Stroke
Learning
Ligands
Neurons
Growth

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Toll-like receptor signaling in neural plasticity and disease. / Okun, Eitan; Griffioen, Kathleen J.; Mattson, Mark P.

In: Trends in Neurosciences, Vol. 34, No. 5, 05.2011, p. 269-281.

Research output: Contribution to journalArticle

Okun, Eitan ; Griffioen, Kathleen J. ; Mattson, Mark P. / Toll-like receptor signaling in neural plasticity and disease. In: Trends in Neurosciences. 2011 ; Vol. 34, No. 5. pp. 269-281.
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