Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis

Matthew D. Neal, Chhinder P. Sodhi, Hongpeng Jia, Mitchell Dyer, Charlotte E. Egan, Ibrahim Yazji, Misty Good, Amin Afrazi, Ryan Marino, Dennis Slagle, Congrong Ma, Maria F. Branca, Thomas Prindle, Zachary Grant, John Ozolek, David J. Hackam

Research output: Contribution to journalArticle

Abstract

Background: Factors that regulate intestinal stem cell (ISC) proliferation and apoptosis are unknown. Results: Toll-like receptor 4 (TLR4) is expressed on ISCs and regulates their proliferation and apoptosis, which is critical in the pathogenesis of necrotizing enterocolitis (NEC). Conclusion: TLR4 regulates ISC proliferation and apoptosis. Significance: This is the first study showing that ISC regulation by microbial receptors contributes to NEC pathogenesis.

Original languageEnglish (US)
Pages (from-to)37296-37308
Number of pages13
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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