Tolerance to cryptococcal polysaccharide in cured cryptococcosis patients: Failure of antibody secretion in vitro

D. K. Henderson, V. L. Kan, J. E. Bennett

Research output: Contribution to journalArticlepeer-review

Abstract

Ten patients cured of cryptococcosis and 14 normal volunteers were immunized with subcutaneous injections of cryptococcal polysaccharide (CPS). Peripheral mononuclear cells cultured from the volunteers 7 days post-immunization secreted significant amounts of IgM, IgA and IgG antibody to CPS in vitro. In cell cultures obtained 7 days after immunization of patients, nine of 10 had neither IgM nor IgG antibody response to CPS, and eight lacked anti-CPS IgA. Depletion of T lymphocytes from patients' cell cultures did not promote specific antibody secretion to CPS by B cells. The intense, prolonged antigenaemia with CPS that accompanies cryptococcosis may be responsible for the failure of cured patients to have circulating anti-CPS-secreting cells after immunization.

Original languageEnglish (US)
Pages (from-to)639-646
Number of pages8
JournalClinical and Experimental Immunology
Volume65
Issue number3
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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