Tolerance of preschoolers to two dosage strengths of vitamin A preparation

Rodolfo F. Florentino, Celeste C. Tanchoco, Adelisa C. Ramos, Teresa S. Mendoza, Erlinda P. Natividad, Juamina Belen M Tangco, Alfred Sommer

Research output: Contribution to journalArticle

Abstract

The tolerance to two alternative large-dosage strengths of vitamin A preparation was determined in a double-blind study involving 2471 children in two municipalities in the Philippines. Each child, aged 1-6 y, not suffering from active xerophthalmia or from nausea and/or vomiting, headache, diarrhea, and fever, was randomly given 1 mL of a syrupy suspension later identified to contain 0, 60, or 30 mg vitamin A. Clinical evaluation of subjects was done by physicians 24 h and 1 wk after dosing. Nausea and/or vomiting and headache were twice as common among children given 60 mg than those given 30 mg. Severe vomiting (1.2%) was confined to those given 60 mg. Almost all experienced their symptoms within 24 h after dosing; symptoms lasted for no more than 12-24 h. The incidence of diarrhea and fever for vitamin A recipients was not significantly different from that of those receiving placebo.

Original languageEnglish (US)
Pages (from-to)694-700
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume52
Issue number4
StatePublished - Oct 1990

Fingerprint

preschool children
vomiting
Vitamin A
Vomiting
vitamin A
nausea
headache
Nausea
signs and symptoms (animals and humans)
fever
Headache
Diarrhea
diarrhea
Fever
dosage
xerophthalmia
Xerophthalmia
Philippines
physicians
Double-Blind Method

Keywords

  • High dose
  • Side effects
  • Supplement
  • Toxicity
  • Trial
  • Vitamin A

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Florentino, R. F., Tanchoco, C. C., Ramos, A. C., Mendoza, T. S., Natividad, E. P., Tangco, J. B. M., & Sommer, A. (1990). Tolerance of preschoolers to two dosage strengths of vitamin A preparation. American Journal of Clinical Nutrition, 52(4), 694-700.

Tolerance of preschoolers to two dosage strengths of vitamin A preparation. / Florentino, Rodolfo F.; Tanchoco, Celeste C.; Ramos, Adelisa C.; Mendoza, Teresa S.; Natividad, Erlinda P.; Tangco, Juamina Belen M; Sommer, Alfred.

In: American Journal of Clinical Nutrition, Vol. 52, No. 4, 10.1990, p. 694-700.

Research output: Contribution to journalArticle

Florentino, RF, Tanchoco, CC, Ramos, AC, Mendoza, TS, Natividad, EP, Tangco, JBM & Sommer, A 1990, 'Tolerance of preschoolers to two dosage strengths of vitamin A preparation', American Journal of Clinical Nutrition, vol. 52, no. 4, pp. 694-700.
Florentino RF, Tanchoco CC, Ramos AC, Mendoza TS, Natividad EP, Tangco JBM et al. Tolerance of preschoolers to two dosage strengths of vitamin A preparation. American Journal of Clinical Nutrition. 1990 Oct;52(4):694-700.
Florentino, Rodolfo F. ; Tanchoco, Celeste C. ; Ramos, Adelisa C. ; Mendoza, Teresa S. ; Natividad, Erlinda P. ; Tangco, Juamina Belen M ; Sommer, Alfred. / Tolerance of preschoolers to two dosage strengths of vitamin A preparation. In: American Journal of Clinical Nutrition. 1990 ; Vol. 52, No. 4. pp. 694-700.
@article{9a31a3982a66460294555af21aa465d2,
title = "Tolerance of preschoolers to two dosage strengths of vitamin A preparation",
abstract = "The tolerance to two alternative large-dosage strengths of vitamin A preparation was determined in a double-blind study involving 2471 children in two municipalities in the Philippines. Each child, aged 1-6 y, not suffering from active xerophthalmia or from nausea and/or vomiting, headache, diarrhea, and fever, was randomly given 1 mL of a syrupy suspension later identified to contain 0, 60, or 30 mg vitamin A. Clinical evaluation of subjects was done by physicians 24 h and 1 wk after dosing. Nausea and/or vomiting and headache were twice as common among children given 60 mg than those given 30 mg. Severe vomiting (1.2{\%}) was confined to those given 60 mg. Almost all experienced their symptoms within 24 h after dosing; symptoms lasted for no more than 12-24 h. The incidence of diarrhea and fever for vitamin A recipients was not significantly different from that of those receiving placebo.",
keywords = "High dose, Side effects, Supplement, Toxicity, Trial, Vitamin A",
author = "Florentino, {Rodolfo F.} and Tanchoco, {Celeste C.} and Ramos, {Adelisa C.} and Mendoza, {Teresa S.} and Natividad, {Erlinda P.} and Tangco, {Juamina Belen M} and Alfred Sommer",
year = "1990",
month = "10",
language = "English (US)",
volume = "52",
pages = "694--700",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "4",

}

TY - JOUR

T1 - Tolerance of preschoolers to two dosage strengths of vitamin A preparation

AU - Florentino, Rodolfo F.

AU - Tanchoco, Celeste C.

AU - Ramos, Adelisa C.

AU - Mendoza, Teresa S.

AU - Natividad, Erlinda P.

AU - Tangco, Juamina Belen M

AU - Sommer, Alfred

PY - 1990/10

Y1 - 1990/10

N2 - The tolerance to two alternative large-dosage strengths of vitamin A preparation was determined in a double-blind study involving 2471 children in two municipalities in the Philippines. Each child, aged 1-6 y, not suffering from active xerophthalmia or from nausea and/or vomiting, headache, diarrhea, and fever, was randomly given 1 mL of a syrupy suspension later identified to contain 0, 60, or 30 mg vitamin A. Clinical evaluation of subjects was done by physicians 24 h and 1 wk after dosing. Nausea and/or vomiting and headache were twice as common among children given 60 mg than those given 30 mg. Severe vomiting (1.2%) was confined to those given 60 mg. Almost all experienced their symptoms within 24 h after dosing; symptoms lasted for no more than 12-24 h. The incidence of diarrhea and fever for vitamin A recipients was not significantly different from that of those receiving placebo.

AB - The tolerance to two alternative large-dosage strengths of vitamin A preparation was determined in a double-blind study involving 2471 children in two municipalities in the Philippines. Each child, aged 1-6 y, not suffering from active xerophthalmia or from nausea and/or vomiting, headache, diarrhea, and fever, was randomly given 1 mL of a syrupy suspension later identified to contain 0, 60, or 30 mg vitamin A. Clinical evaluation of subjects was done by physicians 24 h and 1 wk after dosing. Nausea and/or vomiting and headache were twice as common among children given 60 mg than those given 30 mg. Severe vomiting (1.2%) was confined to those given 60 mg. Almost all experienced their symptoms within 24 h after dosing; symptoms lasted for no more than 12-24 h. The incidence of diarrhea and fever for vitamin A recipients was not significantly different from that of those receiving placebo.

KW - High dose

KW - Side effects

KW - Supplement

KW - Toxicity

KW - Trial

KW - Vitamin A

UR - http://www.scopus.com/inward/record.url?scp=0024996277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024996277&partnerID=8YFLogxK

M3 - Article

VL - 52

SP - 694

EP - 700

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 4

ER -