Tolerance of a sterile isotonic electrolyte solution containing select recombinant growth factors in neonates recovering from necrotizing enterocolitis

Victoria Lima-Rogel, Darlene A. Calhoun, Akhil Maheshwari, Abraham Torres-Montes, Raul Roque-Sanchez, Maria G. Garcia, Robert D. Christensen

Research output: Contribution to journalArticle

Abstract

Objective: To assess the tolerance of a sterile isotonic electrolyte solution containing select recombinant growth factors enternally administered in neonates who were NPO because of necrotizing enterocolitis (NEC). Study Design: A phase I trial was accomplished among 30 neonates. Patients received 5, 10, or 20 mL enterally of the study solution/kg/day divided into every 3-hour dosing, for 3 days prior to when feedings of milk were to resume. The occurrence of emesis, gastric residuals, diarrhea, bloody stools, abdominal distention, skin rashes and death were sought. Results: Gestational ages ranged from 25.2 to 41.1 weeks. A total of 16 neonates had Stage IA NEC, six Stage IB, and eight Stage IIA. The solutions was well tolerated in all 30; none developed diarrhea, guaiac positive or bloody stools, or abdominal distention. Administration of the solution was not prematurely discontinued in any infant. Two neonates died secondary to late-onset sepsis remote from the study period. Conclusions: Enteral administration of a sterile isotonic electrolyte solution containing select recombinant growth factors was well tolerated by neonate with NEC.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalJournal of Perinatology
Volume23
Issue number3
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

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Isotonic Solutions
Necrotizing Enterocolitis
Electrolytes
Intercellular Signaling Peptides and Proteins
Newborn Infant
Diarrhea
Guaiac
Exanthema
Gestational Age
Small Intestine
Vomiting
Sepsis
Stomach
Milk

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Tolerance of a sterile isotonic electrolyte solution containing select recombinant growth factors in neonates recovering from necrotizing enterocolitis. / Lima-Rogel, Victoria; Calhoun, Darlene A.; Maheshwari, Akhil; Torres-Montes, Abraham; Roque-Sanchez, Raul; Garcia, Maria G.; Christensen, Robert D.

In: Journal of Perinatology, Vol. 23, No. 3, 01.04.2003, p. 200-204.

Research output: Contribution to journalArticle

Lima-Rogel, Victoria ; Calhoun, Darlene A. ; Maheshwari, Akhil ; Torres-Montes, Abraham ; Roque-Sanchez, Raul ; Garcia, Maria G. ; Christensen, Robert D. / Tolerance of a sterile isotonic electrolyte solution containing select recombinant growth factors in neonates recovering from necrotizing enterocolitis. In: Journal of Perinatology. 2003 ; Vol. 23, No. 3. pp. 200-204.
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