Tolerance, fermentation, and cytokine expression in healthy aged male C57BL/6J mice fed resistant starch

June Zhou, Michael J. Keenan, Jeffrey Keller, Sun O. Fernandez-Kim, Paul J. Pistell, Richard T. Tulley, Anne M. Raggio, Li Shen, Hanjie Zhang, Roy J. Martin, Marc R. Blackman

Research output: Contribution to journalArticle

Abstract

Health benefits of resistant starch (RS), a dietary fermentable fiber, have been well documented in young, but not in old populations. As the essential step of more comprehensive evaluations of RS on healthy aging, we examined the effects of dietary RS on tolerance, colonic fermentation, and cytokine expression in aged mice. Healthy older (18-20 months) C57BL/6J male mice were fed control, 18% RS, or 36% RS diets for 10weeks. Body weight gain, body composition, and fat pad weights did not differ among the three groups after 10weeks, indicating good tolerance of the RS diet. Fermentation indicators (cecum weights, and cecal proglucagon and PYY mRNA expression) were enhanced in an RS dose-dependent manner (p

Original languageEnglish (US)
Pages (from-to)515-518
Number of pages4
JournalMolecular Nutrition and Food Research
Volume56
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Fingerprint

resistant starch
Inbred C57BL Mouse
Starch
Fermentation
cytokines
fermentation
Cytokines
mice
Adipose Tissue
Proglucagon
Diet
Weights and Measures
Cecum
Dietary Fiber
Insurance Benefits
Body Composition
diet
cecum
body fat
Weight Gain

Keywords

  • Adiponectin
  • Aging
  • GLP-1
  • Resistant starch
  • TNFα

ASJC Scopus subject areas

  • Food Science
  • Biotechnology

Cite this

Tolerance, fermentation, and cytokine expression in healthy aged male C57BL/6J mice fed resistant starch. / Zhou, June; Keenan, Michael J.; Keller, Jeffrey; Fernandez-Kim, Sun O.; Pistell, Paul J.; Tulley, Richard T.; Raggio, Anne M.; Shen, Li; Zhang, Hanjie; Martin, Roy J.; Blackman, Marc R.

In: Molecular Nutrition and Food Research, Vol. 56, No. 3, 03.2012, p. 515-518.

Research output: Contribution to journalArticle

Zhou, J, Keenan, MJ, Keller, J, Fernandez-Kim, SO, Pistell, PJ, Tulley, RT, Raggio, AM, Shen, L, Zhang, H, Martin, RJ & Blackman, MR 2012, 'Tolerance, fermentation, and cytokine expression in healthy aged male C57BL/6J mice fed resistant starch', Molecular Nutrition and Food Research, vol. 56, no. 3, pp. 515-518. https://doi.org/10.1002/mnfr.201100521
Zhou, June ; Keenan, Michael J. ; Keller, Jeffrey ; Fernandez-Kim, Sun O. ; Pistell, Paul J. ; Tulley, Richard T. ; Raggio, Anne M. ; Shen, Li ; Zhang, Hanjie ; Martin, Roy J. ; Blackman, Marc R. / Tolerance, fermentation, and cytokine expression in healthy aged male C57BL/6J mice fed resistant starch. In: Molecular Nutrition and Food Research. 2012 ; Vol. 56, No. 3. pp. 515-518.
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