Tolerance and Autoimmunity

Noel R. Rose

Research output: Contribution to journalArticlepeer-review


Long-lasting tolerance can be produced by prenatal or perinatal exposure to foreign antigens. Self-tolerance results from embryonic exposure to antigens of the host itself. Several mechanisms that contribute to self-tolerance have been described. They include clonal deletion, anergy, and active suppression. A failure in these mechanisms may lead to autoimmune disease. Some important human diseases are associated with autoimmunity, and immunomethods are regularly employed for their diagnosis. In the future immunomethods will prove to be valuable for the identification of subjects at risk of developing autoimmune disease, thereby permitting preventive interventions.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
Issue number2
StatePublished - Apr 1993
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


Dive into the research topics of 'Tolerance and Autoimmunity'. Together they form a unique fingerprint.

Cite this