Tobacco use and neurogenesis: A theoretical review of pathophysiological mechanism affecting the outcome of peripheral nerve regeneration

Francisco Rodriguez-Fontan, Bradley Reeves, Krystle Tuaño, Salih Colakoglu, Laura D' Agostino, Rodrigo Banegas

Research output: Contribution to journalReview articlepeer-review

Abstract

Peripheral nerve injury often requires medical intervention. Unfortunately, many patients never have a full recovery, despite a multi-disciplinary approach, including operative intervention and physical and/or occupational therapy. Outcomes are multifactorial, but are largely affected by the original injury severity, and patient comorbidities. A lcoholism, diabetes mellitus and ageing may detrimentally affect the outcomes of nerve injury; however little is known about tobacco's potential impact on nerve regeneration. Tobacco has known immunomodulatory effects, which suggests that it might affect peripheral nerve regeneration and functional recovery following injury. This review characterizes the effects of tobacco use on the complex cellular and chemokine interactions in peripheral nerve regeneration.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalJournal of Orthopaedics
Volume22
DOIs
StatePublished - Nov 1 2020
Externally publishedYes

Keywords

  • Immunomodulation
  • Neurogenesis
  • Peripheral nerve injury
  • Peripheral nerve regeneration
  • Smoking
  • Tobacco

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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