To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

Sebastian Boeltz, Poorya Amini, Hans Joachim Anders, Felipe A Andrade, Rostyslav Bilyy, Simon Chatfield, Iwona Cichon, Danielle M. Clancy, Jyaysi Desai, Tetiana Dumych, Nishant Dwivedi, Rachael Ann Gordon, Jonas Hahn, Andrés Hidalgo, Markus H. Hoffmann, Mariana J. Kaplan, Jason S. Knight, Elzbieta Kolaczkowska, Paul Kubes, Moritz Leppkes & 29 others Angelo A. Manfredi, Seamus J. Martin, Christian Maueröder, Norma Maugeri, Ioannis Mitroulis, Luis E. Munoz, Daigo Nakazawa, Indira Neeli, Victor Nizet, Elmar Pieterse, Marko Z. Radic, Christiane Reinwald, Konstantinos Ritis, Patrizia Rovere-Querini, Michal Santocki, Christine Schauer, Georg Schett, Mark Jay Shlomchik, Hans Uwe Simon, Panagiotis Skendros, Darko Stojkov, Peter Vandenabeele, Tom Vanden Berghe, Johan van der Vlag, Ljubomir Vitkov, Maren von Köckritz-Blickwede, Shida Yousefi, Alexander Zarbock, Martin Herrmann

Research output: Contribution to journalArticle

Abstract

Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.

Original languageEnglish (US)
JournalCell Death and Differentiation
DOIs
StateAccepted/In press - Jan 1 2019

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Dissent and Disputes
Research
Extracellular Traps
Cell Death
Anti-Inflammatory Agents
DNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. / Boeltz, Sebastian; Amini, Poorya; Anders, Hans Joachim; Andrade, Felipe A; Bilyy, Rostyslav; Chatfield, Simon; Cichon, Iwona; Clancy, Danielle M.; Desai, Jyaysi; Dumych, Tetiana; Dwivedi, Nishant; Gordon, Rachael Ann; Hahn, Jonas; Hidalgo, Andrés; Hoffmann, Markus H.; Kaplan, Mariana J.; Knight, Jason S.; Kolaczkowska, Elzbieta; Kubes, Paul; Leppkes, Moritz; Manfredi, Angelo A.; Martin, Seamus J.; Maueröder, Christian; Maugeri, Norma; Mitroulis, Ioannis; Munoz, Luis E.; Nakazawa, Daigo; Neeli, Indira; Nizet, Victor; Pieterse, Elmar; Radic, Marko Z.; Reinwald, Christiane; Ritis, Konstantinos; Rovere-Querini, Patrizia; Santocki, Michal; Schauer, Christine; Schett, Georg; Shlomchik, Mark Jay; Simon, Hans Uwe; Skendros, Panagiotis; Stojkov, Darko; Vandenabeele, Peter; Berghe, Tom Vanden; van der Vlag, Johan; Vitkov, Ljubomir; von Köckritz-Blickwede, Maren; Yousefi, Shida; Zarbock, Alexander; Herrmann, Martin.

In: Cell Death and Differentiation, 01.01.2019.

Research output: Contribution to journalArticle

Boeltz, S, Amini, P, Anders, HJ, Andrade, FA, Bilyy, R, Chatfield, S, Cichon, I, Clancy, DM, Desai, J, Dumych, T, Dwivedi, N, Gordon, RA, Hahn, J, Hidalgo, A, Hoffmann, MH, Kaplan, MJ, Knight, JS, Kolaczkowska, E, Kubes, P, Leppkes, M, Manfredi, AA, Martin, SJ, Maueröder, C, Maugeri, N, Mitroulis, I, Munoz, LE, Nakazawa, D, Neeli, I, Nizet, V, Pieterse, E, Radic, MZ, Reinwald, C, Ritis, K, Rovere-Querini, P, Santocki, M, Schauer, C, Schett, G, Shlomchik, MJ, Simon, HU, Skendros, P, Stojkov, D, Vandenabeele, P, Berghe, TV, van der Vlag, J, Vitkov, L, von Köckritz-Blickwede, M, Yousefi, S, Zarbock, A & Herrmann, M 2019, 'To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps', Cell Death and Differentiation. https://doi.org/10.1038/s41418-018-0261-x
Boeltz, Sebastian ; Amini, Poorya ; Anders, Hans Joachim ; Andrade, Felipe A ; Bilyy, Rostyslav ; Chatfield, Simon ; Cichon, Iwona ; Clancy, Danielle M. ; Desai, Jyaysi ; Dumych, Tetiana ; Dwivedi, Nishant ; Gordon, Rachael Ann ; Hahn, Jonas ; Hidalgo, Andrés ; Hoffmann, Markus H. ; Kaplan, Mariana J. ; Knight, Jason S. ; Kolaczkowska, Elzbieta ; Kubes, Paul ; Leppkes, Moritz ; Manfredi, Angelo A. ; Martin, Seamus J. ; Maueröder, Christian ; Maugeri, Norma ; Mitroulis, Ioannis ; Munoz, Luis E. ; Nakazawa, Daigo ; Neeli, Indira ; Nizet, Victor ; Pieterse, Elmar ; Radic, Marko Z. ; Reinwald, Christiane ; Ritis, Konstantinos ; Rovere-Querini, Patrizia ; Santocki, Michal ; Schauer, Christine ; Schett, Georg ; Shlomchik, Mark Jay ; Simon, Hans Uwe ; Skendros, Panagiotis ; Stojkov, Darko ; Vandenabeele, Peter ; Berghe, Tom Vanden ; van der Vlag, Johan ; Vitkov, Ljubomir ; von Köckritz-Blickwede, Maren ; Yousefi, Shida ; Zarbock, Alexander ; Herrmann, Martin. / To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. In: Cell Death and Differentiation. 2019.
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AU - Amini, Poorya

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AU - Andrade, Felipe A

AU - Bilyy, Rostyslav

AU - Chatfield, Simon

AU - Cichon, Iwona

AU - Clancy, Danielle M.

AU - Desai, Jyaysi

AU - Dumych, Tetiana

AU - Dwivedi, Nishant

AU - Gordon, Rachael Ann

AU - Hahn, Jonas

AU - Hidalgo, Andrés

AU - Hoffmann, Markus H.

AU - Kaplan, Mariana J.

AU - Knight, Jason S.

AU - Kolaczkowska, Elzbieta

AU - Kubes, Paul

AU - Leppkes, Moritz

AU - Manfredi, Angelo A.

AU - Martin, Seamus J.

AU - Maueröder, Christian

AU - Maugeri, Norma

AU - Mitroulis, Ioannis

AU - Munoz, Luis E.

AU - Nakazawa, Daigo

AU - Neeli, Indira

AU - Nizet, Victor

AU - Pieterse, Elmar

AU - Radic, Marko Z.

AU - Reinwald, Christiane

AU - Ritis, Konstantinos

AU - Rovere-Querini, Patrizia

AU - Santocki, Michal

AU - Schauer, Christine

AU - Schett, Georg

AU - Shlomchik, Mark Jay

AU - Simon, Hans Uwe

AU - Skendros, Panagiotis

AU - Stojkov, Darko

AU - Vandenabeele, Peter

AU - Berghe, Tom Vanden

AU - van der Vlag, Johan

AU - Vitkov, Ljubomir

AU - von Köckritz-Blickwede, Maren

AU - Yousefi, Shida

AU - Zarbock, Alexander

AU - Herrmann, Martin

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