Abstract
Neurodegenerative disorders such as Alzheimer's disease are characterized by increased intracellular and extracellular concentrations of the astrocytic proteins glial fibrillary acidic protein (GFAP) and S100B. The present study examined the potential contribution of tumor necrosis factor alpha (TNFα) to these changes by measuring astrocyte viability along with the intracellular and extracellular expression of GFAP and S100B following exposure to this cytokine. Although TNFα did not affect astrocyte viability, the extracellular levels of both proteins were increased three-fold with associated reductions in immunocytochemical labeling.
Original language | English (US) |
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Pages (from-to) | 1709-1715 |
Number of pages | 7 |
Journal | Journal of Neural Transmission |
Volume | 113 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 2006 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Astrocytes
- GFAP
- S100B
- TNFα
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry