TNF alpha affects the expression of GFAP and S100B: Implications for Alzheimer's disease

M. M. Edwards, S. R. Robinson

Research output: Contribution to journalArticle

Abstract

Neurodegenerative disorders such as Alzheimer's disease are characterized by increased intracellular and extracellular concentrations of the astrocytic proteins glial fibrillary acidic protein (GFAP) and S100B. The present study examined the potential contribution of tumor necrosis factor alpha (TNFα) to these changes by measuring astrocyte viability along with the intracellular and extracellular expression of GFAP and S100B following exposure to this cytokine. Although TNFα did not affect astrocyte viability, the extracellular levels of both proteins were increased three-fold with associated reductions in immunocytochemical labeling.

Original languageEnglish (US)
Pages (from-to)1709-1715
Number of pages7
JournalJournal of Neural Transmission
Volume113
Issue number11
DOIs
StatePublished - Nov 1 2006
Externally publishedYes

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Keywords

  • Alzheimer's disease
  • Astrocytes
  • GFAP
  • S100B
  • TNFα

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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