TMPRSS2 and COVID-19: Serendipity or opportunity for intervention?

Konrad H. Stopsack, Lorelei A. Mucci, Emmanuel S. Antonarakis, Peter S. Nelson, Philip W. Kantoff

Research output: Contribution to journalArticle

Abstract

TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.

Original languageEnglish (US)
JournalCancer discovery
DOIs
StateAccepted/In press - Apr 10 2020

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ASJC Scopus subject areas

  • Oncology

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