TMPRSS2 and COVID-19: Serendipity or opportunity for intervention?

Konrad H. Stopsack; Lorelei A. Mucci; Emmanuel S. Antonarakis; Peter S. Nelson; Philip W. Kantoff

doi:10.1158/2159-8290.CD-20-0451

TMPRSS2 and COVID-19: Serendipity or opportunity for intervention?

Konrad H. Stopsack, Lorelei A. Mucci, Emmanuel S. Antonarakis, Peter S. Nelson, Philip W. Kantoff

School of Medicine

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.

Original language	English (US)
Pages (from-to)	779-782
Number of pages	4
Journal	Cancer discovery
Volume	10
Issue number	6
DOIs	https://doi.org/10.1158/2159-8290.CD-20-0451
State	Published - Jun 2020

ASJC Scopus subject areas

Oncology

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title = "TMPRSS2 and COVID-19: Serendipity or opportunity for intervention?",

abstract = "TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.",

author = "Stopsack, {Konrad H.} and Mucci, {Lorelei A.} and Antonarakis, {Emmanuel S.} and Nelson, {Peter S.} and Kantoff, {Philip W.}",

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AU - Mucci, Lorelei A.

AU - Antonarakis, Emmanuel S.

AU - Nelson, Peter S.

AU - Kantoff, Philip W.

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AB - TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.

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TMPRSS2 and COVID-19: Serendipity or opportunity for intervention?

Abstract

ASJC Scopus subject areas

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