TLR-4-dependent and -independent mechanisms of fetal brain injury in the setting of preterm birth

Kelsey Breen; Amy Brown; Irina Burd; Jinghua Chai; Alexander Friedman; Michal A. Elovitz

doi:10.1177/1933719112438439

TLR-4-dependent and -independent mechanisms of fetal brain injury in the setting of preterm birth

Kelsey Breen, Amy Brown, Irina Burd, Jinghua Chai, Alexander Friedman, Michal A. Elovitz

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

In this study, we sought to assess how essential activation of toll-like receptor 4 (TLR-4) is to fetal brain injury from intrauterine inflammation. Both wild-type and TLR-4 mutant fetal central nervous system cells were exposed to inflammation using lipopolysaccharide in vivo or in vitro. Inflammation could not induce neuronal injury in the absence of glial cells, in either wild-type or TLR-4 mutant neurons. However, injured neurons could induce injury in other neurons regardless of TLR-4 competency. Our results indicate that initiation of neuronal injury is a TLR-4-dependent event, while propagation is a TLR-4-independent event.

Original language	English (US)
Pages (from-to)	839-850
Number of pages	12
Journal	Reproductive Sciences
Volume	19
Issue number	8
DOIs	https://doi.org/10.1177/1933719112438439
State	Published - Aug 2012
Externally published	Yes

Keywords

LPS
TLR-4
neuronal injury
prenatal inflammation

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1177/1933719112438439

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abstract = "In this study, we sought to assess how essential activation of toll-like receptor 4 (TLR-4) is to fetal brain injury from intrauterine inflammation. Both wild-type and TLR-4 mutant fetal central nervous system cells were exposed to inflammation using lipopolysaccharide in vivo or in vitro. Inflammation could not induce neuronal injury in the absence of glial cells, in either wild-type or TLR-4 mutant neurons. However, injured neurons could induce injury in other neurons regardless of TLR-4 competency. Our results indicate that initiation of neuronal injury is a TLR-4-dependent event, while propagation is a TLR-4-independent event.",

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AU - Burd, Irina

AU - Chai, Jinghua

AU - Friedman, Alexander

AU - Elovitz, Michal A.

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TLR-4-dependent and -independent mechanisms of fetal brain injury in the setting of preterm birth

Abstract

Keywords

ASJC Scopus subject areas

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