Titin, a huge, elastic sarcomeric protein with a probable role in morphogenesis

Alice B. Fulton, William B. Isaacs

Research output: Contribution to journalReview article


Titin, the largest protein identified to date (over 1 μm long, almost 3 million daltons in mass) is the third most abundant component of the sarcomere. In the mature myofibril, titin molecules span from M line to Z line, forming a third filament system which provides sarcomeric alignment and elastic recoil. In the developing sarcomere, accumulating evidence from studies both in vivo and in vitro implicates titin as part of a morphogenetic scaffolding, upon which critical events in myofibrillogenesis are coordinated in a time‐ and spacedependent manner.

Original languageEnglish (US)
Pages (from-to)157-161
Number of pages5
Issue number4
StatePublished - Apr 1991


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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