TY - JOUR
T1 - Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells
AU - Sojka, Dorothy K.
AU - Plougastel-Douglas, Beatrice
AU - Yang, Liping
AU - Pak-Wittel, Melissa A.
AU - Artyomov, Maxim N.
AU - Ivanova, Yulia
AU - Zhong, Chao
AU - Chase, Julie M.
AU - Rothman, Paul B.
AU - Yu, Jenny
AU - Riley, Joan K.
AU - Zhu, Jinfang
AU - Tian, Zhigang
AU - Yokoyama, Wayne M.
PY - 2014/4/8
Y1 - 2014/4/8
N2 - Natural killer (NK) cells belong to the innate immune system; they can control virus infections and developing tumors by cytotoxicity and producing inflammatory cytokines. Most studies of mouse NK cells, however, have focused on conventional NK (cNK) cells in the spleen. Recently, we described two populations of liver NK cells, tissue-resident NK (trNK) cells and those resembling splenic cNK cells. However, their lineage relationship was unclear; trNK cells could be developing cNK cells, related to thymic NK cells, or a lineage distinct from both cNK and thymic NK cells. Herein we used detailed transcriptomic, flow cytometric, and functional analysis and transcription factor-deficient mice to determine that liver trNK cells form a distinct lineage from cNK and thymic NK cells. Taken together with analysis of trNK cells in other tissues, there are at least four distinct lineages of NK cells: cNK, thymic, liver (and skin) trNK, and uterine trNK cells.
AB - Natural killer (NK) cells belong to the innate immune system; they can control virus infections and developing tumors by cytotoxicity and producing inflammatory cytokines. Most studies of mouse NK cells, however, have focused on conventional NK (cNK) cells in the spleen. Recently, we described two populations of liver NK cells, tissue-resident NK (trNK) cells and those resembling splenic cNK cells. However, their lineage relationship was unclear; trNK cells could be developing cNK cells, related to thymic NK cells, or a lineage distinct from both cNK and thymic NK cells. Herein we used detailed transcriptomic, flow cytometric, and functional analysis and transcription factor-deficient mice to determine that liver trNK cells form a distinct lineage from cNK and thymic NK cells. Taken together with analysis of trNK cells in other tissues, there are at least four distinct lineages of NK cells: cNK, thymic, liver (and skin) trNK, and uterine trNK cells.
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U2 - 10.7554/eLife.01659
DO - 10.7554/eLife.01659
M3 - Article
C2 - 24714492
AN - SCOPUS:84898475376
SN - 2050-084X
VL - 2014
JO - eLife
JF - eLife
IS - 3
M1 - e01659
ER -