Tissue-resident dendritic cells and diseases involving dendritic cell malfunction

Keqiang Chen, Ji Ming Wang, Ruoxi Yuan, Xiang Yi, Liangzhu Li, Wanghua Gong, Tianshu Yang, Liwu Li, Shaobo Su

Research output: Contribution to journalReview articlepeer-review

Abstract

Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident populations, a third tissue-derived population resides the spleen and lymph nodes (LNs), different subsets of tissue-derived DCs have been identified in the blood, spleen, lymph nodes, skin, lung, liver, gut and kidney to maintain the tolerance and control immune responses. Tissue-resident DCs express different receptors for microbe-associated molecular patterns (MAMPs) and damage-associated molecular patterns (DAMPs), which were activated to promote the production of pro- or anti-inflammatory cytokines. Malfunction of DCs contributes to diseases such as autoimmunity, allergy, and cancer. It is therefore important to update the knowledge about resident DC subsets and diseases associated with DC malfunction.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalInternational immunopharmacology
Volume34
DOIs
StatePublished - May 1 2016
Externally publishedYes

Keywords

  • Autoimmunity
  • Cancer
  • DC-related diseases
  • Dendritic cells
  • Resident DCs

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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