TY - JOUR
T1 - Tissue-resident dendritic cells and diseases involving dendritic cell malfunction
AU - Chen, Keqiang
AU - Wang, Ji Ming
AU - Yuan, Ruoxi
AU - Yi, Xiang
AU - Li, Liangzhu
AU - Gong, Wanghua
AU - Yang, Tianshu
AU - Li, Liwu
AU - Su, Shaobo
N1 - Publisher Copyright:
© Published by Elsevier B.V.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident populations, a third tissue-derived population resides the spleen and lymph nodes (LNs), different subsets of tissue-derived DCs have been identified in the blood, spleen, lymph nodes, skin, lung, liver, gut and kidney to maintain the tolerance and control immune responses. Tissue-resident DCs express different receptors for microbe-associated molecular patterns (MAMPs) and damage-associated molecular patterns (DAMPs), which were activated to promote the production of pro- or anti-inflammatory cytokines. Malfunction of DCs contributes to diseases such as autoimmunity, allergy, and cancer. It is therefore important to update the knowledge about resident DC subsets and diseases associated with DC malfunction.
AB - Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident populations, a third tissue-derived population resides the spleen and lymph nodes (LNs), different subsets of tissue-derived DCs have been identified in the blood, spleen, lymph nodes, skin, lung, liver, gut and kidney to maintain the tolerance and control immune responses. Tissue-resident DCs express different receptors for microbe-associated molecular patterns (MAMPs) and damage-associated molecular patterns (DAMPs), which were activated to promote the production of pro- or anti-inflammatory cytokines. Malfunction of DCs contributes to diseases such as autoimmunity, allergy, and cancer. It is therefore important to update the knowledge about resident DC subsets and diseases associated with DC malfunction.
KW - Autoimmunity
KW - Cancer
KW - DC-related diseases
KW - Dendritic cells
KW - Resident DCs
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U2 - 10.1016/j.intimp.2016.02.007
DO - 10.1016/j.intimp.2016.02.007
M3 - Review article
C2 - 26906720
AN - SCOPUS:84958742197
SN - 1567-5769
VL - 34
SP - 1
EP - 15
JO - International immunopharmacology
JF - International immunopharmacology
ER -