Tissue repair and stem cell renewal in carcinogenesis

Philip A. Beachy, Sunil S. Karhadkar, David M. Berman

Research output: Contribution to journalArticle

Abstract

Cancer is increasingly being viewed as a stem cell disease, both in its propagation by a minority of cells with stem-cell-like properties and in its possible derivation from normal tissue stem cells. But stem cell activity is tightly controlled, raising the question of how normal regulation might be subverted in carcinogenesis. The long-known association between cancer and chronic tissue injury, and the more recently appreciated roles of Hedgehog and Wnt signalling pathways in tissue regeneration, stem cell renewal and cancer growth together suggest that carcinogenesis proceeds by misappropriating homeostatic mechanisms that govern tissue repair and stem cell self-renewal.

Original languageEnglish (US)
Pages (from-to)324-331
Number of pages8
JournalNature
Volume432
Issue number7015
DOIs
StatePublished - Nov 18 2004

ASJC Scopus subject areas

  • General

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    Beachy, P. A., Karhadkar, S. S., & Berman, D. M. (2004). Tissue repair and stem cell renewal in carcinogenesis. Nature, 432(7015), 324-331. https://doi.org/10.1038/nature03100