Tissue oxygen saturation mapping with magnetic resonance imaging

Thomas Christen, Pierre Bouzat, Nicolas Pannetier, Nicolas Coquery, Anaïck Moisan, Benjamin Lemasson, Sébastien Thomas, Emmanuelle Grillon, Olivier Detante, Chantal Rémy, Jean François Payen, Emmanuel Luc Barbier

Research output: Contribution to journalArticlepeer-review

Abstract

A quantitative estimate of cerebral blood oxygen saturation is of critical importance in the investigation of cerebrovascular disease. While positron emission tomography can map in vivo the oxygen level in blood, it has limited availability and requires ionizing radiation. Magnetic resonance imaging (MRI) offers an alternative through the blood oxygen level-dependent contrast. Here, we describe an in vivo and non-invasive approach to map brain tissue oxygen saturation (StO2) with high spatial resolution. StO2 obtained with MRI correlated well with results from blood gas analyses for various oxygen and hematocrit challenges. In a stroke model, the hypoxic areas delineated in vivo by MRI spatially matched those observed ex vivo by pimonidazole staining. In a model of diffuse traumatic brain injury, MRI was able to detect even a reduction in StO2 that was too small to be detected by histology. In a F98 glioma model, MRI was able to map oxygenation heterogeneity. Thus, the MRI technique may improve our understanding of the pathophysiology of several brain diseases involving impaired oxygenation.

Original languageEnglish (US)
Pages (from-to)1550-1557
Number of pages8
JournalJournal of Cerebral Blood Flow and Metabolism
Volume34
Issue number9
DOIs
StatePublished - Sep 2014

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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