Tissue microarray analysis of topoisomerase IIα protein in gastric adenocarcinomas: Histogenetic and prognostic implications

Gangshi Wang, Haili Huang, Jie Gao, Ping Chen, Weidi You, Benyan Wu, Mengwei Wang

Research output: Contribution to journalArticle

Abstract

The aim of this study was to: To investigate topoisomerase IIα (topo-IIα) expression and its correlation with clinicopathological parameters in primary gastric cancer patients. Patients and Methods: A tissue microarray including tumor, paired non-tumoral and lymph node metastasis specimens from 210 gastric adenocarcinoma patients was built for immunohistochemical interrogation. The correlation between topo-IIα expression and patient clinicopathological parameters was evaluated by univariate and multivariate analyses. Results: High topo-IIα expression was observed in 30.00% (63/210) of the primary tumors, 25.27% (23/91) of the lymph node metastases and 0.47% (1/210) of the non-tumoral gastric mucosa (p

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalCancer Genomics and Proteomics
Volume8
Issue number3
StatePublished - May 2011

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Tissue Array Analysis
Type II DNA Topoisomerase
Microarrays
Stomach
Adenocarcinoma
Tissue
Tumors
Proteins
Lymph Nodes
Neoplasm Metastasis
Gastric Mucosa
Stomach Neoplasms
Neoplasms
Multivariate Analysis

Keywords

  • Gastric carcinoma
  • Prognosis
  • Tissue microarray
  • Topoisomerase IIα

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cancer Research
  • Biochemistry

Cite this

Tissue microarray analysis of topoisomerase IIα protein in gastric adenocarcinomas : Histogenetic and prognostic implications. / Wang, Gangshi; Huang, Haili; Gao, Jie; Chen, Ping; You, Weidi; Wu, Benyan; Wang, Mengwei.

In: Cancer Genomics and Proteomics, Vol. 8, No. 3, 05.2011, p. 127-133.

Research output: Contribution to journalArticle

Wang, Gangshi ; Huang, Haili ; Gao, Jie ; Chen, Ping ; You, Weidi ; Wu, Benyan ; Wang, Mengwei. / Tissue microarray analysis of topoisomerase IIα protein in gastric adenocarcinomas : Histogenetic and prognostic implications. In: Cancer Genomics and Proteomics. 2011 ; Vol. 8, No. 3. pp. 127-133.
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