Tissue ingrowth into perforated polymethylmethacrylate orbital implants: An experimental study

Denise Miyashita, Fernando Chahud, Gyl Eanes Barros Da Silva, Verônica Batista De Albuquerque, Denny Marcos Garcia, Antonio Augusto Velasco E Cruz

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Purpose: To evaluate the clinical response and fibrovascular ingrowth into perforated acrylic orbital implants in a rabbit model. Methods: Perforated implants were manufactured by drilling channels interconnected at the center in conventional 12- to 13-mm acrylic spheres. The implants were placed in 16 eviscerated eyes with posterior sclerotomy of 16 New Zealand white rabbits. Clinical evaluation was performed daily for the first 14 days after surgery and at 7-day intervals until the end of the study (180 days). Histopathologic analysis was performed at 14, 45, 90, and 180 days after implantation. Hematoxylin-eosin and picrosirius red staining was used to assess the inflammatory reaction and collagen formation. Results: There were no signs of infection, implant exposure, or extrusion in any animal during the study. Tissue ingrowth in the implant center was already detected by 14 days. At the end of the study, there was a dense collagen ingrowth with just a few inflammatory cells inside the implant. No multinucleated giant cells were found in any implant. Conclusions: Similar to porous implants, perforated acrylic implants permit fibrovascular ingrowth from surrounding orbital tissues.

Original languageEnglish (US)
Pages (from-to)160-163
Number of pages4
JournalOphthalmic plastic and reconstructive surgery
Issue number3
StatePublished - May 2013
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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