Tissue engineering for the treatment of short bowel syndrome in children

Laura Y. Martin, Mitchell R. Ladd, Adam Werts, Chhinder Sodhi, John C. March, David Hackam

Research output: Contribution to journalReview article

Abstract

Short bowel syndrome is a major cause of morbidity and mortality in children. Despite decades of experience in the management of short bowel syndrome, current therapy is primarily supportive. Definitive treatment often requires intestinal transplantation, which is associated with significant morbidity and mortality. In order to develop novel approaches to the treatment of short bowel syndrome, we and others have focused on the development of an artificial intestine, by placing intestinal stem cells on a bioscaffold that has an absorptive surface resembling native intestine, and taking advantage of neovascularization to develop a blood supply. This review will explore recent advances in biomaterials, vascularization, and progress toward development of a functional epithelium and mesenchymal niche, highlighting both success and ongoing challenges in the field.

Original languageEnglish (US)
Pages (from-to)249-257
Number of pages9
JournalPediatric Research
Volume83
Issue number1-2
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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