Tissue engineering bioreactors

Sarindr Bhumiratana, Elisa Cimetta, Nina Tandon, Warren Grayson, Milica Radisic, Gordana Vunjak-Novakovic

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

With the advent of tissue engineering over a century later (Langer and Vacanti 1993), bioreactors were again needed to provide precise control of the culture microenvironment and successfully guide the growth of cells in three-dimensional (3D) scaold systems into viable tissues. In multicellular tissues, the complexity of cell-cell interactions makes it considerably more challenging to correlate the eect of experimental parameters with any single outcome measure of “functionality” in the resulting tissue. Indeed various general criteria (e.g., cell number and viability) and tissue-specic properties (e.g., spatial organization of cells and matrix, as well as mechanical, biological, and phenotypic properties) are evaluated to determine successful tissue-engineering outcomes. As a result, the design of tissue engineering bioreactors has evolved signicantly over the last 20 years, yet the guiding principles remain unchanged.

Original languageEnglish (US)
Title of host publicationTissue Engineering
Subtitle of host publicationPrinciples and Practices
PublisherCRC Press
Pages22-1-22-32
ISBN (Electronic)9781439874035
ISBN (Print)9781439874004
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Materials Science(all)

Fingerprint Dive into the research topics of 'Tissue engineering bioreactors'. Together they form a unique fingerprint.

  • Cite this

    Bhumiratana, S., Cimetta, E., Tandon, N., Grayson, W., Radisic, M., & Vunjak-Novakovic, G. (2012). Tissue engineering bioreactors. In Tissue Engineering: Principles and Practices (pp. 22-1-22-32). CRC Press. https://doi.org/10.1201/b13978