Tissue effects of and host response to human papillomavirus infection.

A. B. Jenson, Robert J Kurman, W. D. Lancaster

Research output: Contribution to journalArticle

Abstract

Human papillomaviruses are a heterogeneous group of DNA tumor viruses associated with hyperplastic (warts, condylomata), dysplastic (CIN and VIN), and malignant lesions (carcinomas) of squamous epithelium. Each HPV type is preferentially associated with specific clinical lesions and has an anatomic site preference for either cutaneous or mucosal squamous epithelium. Infection appears to begin in the basal cells. Early gene expression is associated with acanthosis, and late gene expression is associated with appearance of structural antigens and virions in nuclei of cells of the granular layer, usually koilocytotic cells. Malignant transformation of warts and papillomas appears to be related to a variety of factors: (1) infection by certain HPV types (HPV-5, HPV-8, HPV-16, HPV-18, HPV-31); (2) decreased cellular immunity to HPV-associated antigens; and (3) interaction with cofactors such as other microorganisms or sunlight. Spontaneous regression or successful treatment of the benign lesions appears to depend on either naturally acquired or iatrogenically related stimulation of HPV type-specific immunity. The humoral antibody response to HPV particles may be important in preventing infection. In contrast, the local events surrounding regression of warts and condylomata are primarily associated with specific cell-mediated immunity. Local cell-mediated immune responses, particularly cell-associated soluble mediators and stationary macrophage-like cells, may be especially important in the host's immune response to mucosal infections.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalDermatologic Clinics
Volume9
Issue number2
StatePublished - Apr 1991
Externally publishedYes

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Papillomavirus Infections
Warts
Infection
Cellular Immunity
Human papillomavirus 31
DNA Tumor Viruses
Epithelium
Gene Expression
Antigens
Human papillomavirus 18
Mucosal Immunity
Human papillomavirus 16
Sunlight
Papilloma
Cell Nucleus
Virion
Antibody Formation
Squamous Cell Carcinoma
Immunity
Macrophages

ASJC Scopus subject areas

  • Dermatology

Cite this

Tissue effects of and host response to human papillomavirus infection. / Jenson, A. B.; Kurman, Robert J; Lancaster, W. D.

In: Dermatologic Clinics, Vol. 9, No. 2, 04.1991, p. 203-209.

Research output: Contribution to journalArticle

Jenson, A. B. ; Kurman, Robert J ; Lancaster, W. D. / Tissue effects of and host response to human papillomavirus infection. In: Dermatologic Clinics. 1991 ; Vol. 9, No. 2. pp. 203-209.
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