Tissue distribution and variant characterization of human herpesvirus (HHV)-6: Increased prevalence of HHV-6A in patients with multiple sclerosis

N. Akhyani, R. Berti, M. B. Brennan, S. S. Soldan, J. M. Eaton, H. F. McFarland, S. Jacobson

Research output: Contribution to journalArticle

Abstract

Human herpesvirus (HHV)-6 has been associated with the pathogenesis of multiple sclerosis (MS) on the basis of serologic, molecular, and histopathologic studies. This study sought to determine the distribution of HHV-6 in different MS body fluids, including serum, saliva, urine, and peripheral blood lymphocytes. The study results extend the observation of an increased frequency of HHV-6 DNA in serum of patients with MS to the unique detection of viral sequences in urine of a subset of patients with MS. Moreover, the HHV-6 identified in these cell-free compartments was predominantly the HHV-6A variant, which has been reported to be neurotropic. These results support the hypothesis that HHV-6 may contribute to the MS disease process.

Original languageEnglish (US)
Pages (from-to)1321-1325
Number of pages5
JournalJournal of Infectious Diseases
Volume182
Issue number5
DOIs
Publication statusPublished - 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

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