Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor

Annie Huang, Christine E. Campbell, Laura Bonetta, Monica S. McAndrews-Hill, Susan Chilton-Macneill, Max J. Coppes, David J. Law, Andrew P Feinberg, Herman Yeger, Bryan R G Williams

Research output: Contribution to journalArticle

Abstract

The Wilms tumor locus on chromosome lip 13 has been mapped to a region defined by overlapping, tumor-specific deletions. Complementary DNA clones representing transcripts of 2.5 (WIT-1) and 3.5 kb (WIT-2) mapping to this region were isolated from a kidney complementary DNA library. Expression of WIT-1 and WIT-2 was restricted to kidney and spleen. RNase protection revealed divergent transcription of WIT-1 and WIT-2, originating from a DNA region of

Original languageEnglish (US)
Pages (from-to)991-994
Number of pages4
JournalScience
Volume250
Issue number4983
StatePublished - Nov 16 1990
Externally publishedYes

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Wilms Tumor
Complementary DNA
Kidney
Chromosomes, Human, Pair 13
Ribonucleases
Lip
Gene Library
Neoplasms
Spleen
Clone Cells
DNA

ASJC Scopus subject areas

  • General

Cite this

Huang, A., Campbell, C. E., Bonetta, L., McAndrews-Hill, M. S., Chilton-Macneill, S., Coppes, M. J., ... Williams, B. R. G. (1990). Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor. Science, 250(4983), 991-994.

Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor. / Huang, Annie; Campbell, Christine E.; Bonetta, Laura; McAndrews-Hill, Monica S.; Chilton-Macneill, Susan; Coppes, Max J.; Law, David J.; Feinberg, Andrew P; Yeger, Herman; Williams, Bryan R G.

In: Science, Vol. 250, No. 4983, 16.11.1990, p. 991-994.

Research output: Contribution to journalArticle

Huang, A, Campbell, CE, Bonetta, L, McAndrews-Hill, MS, Chilton-Macneill, S, Coppes, MJ, Law, DJ, Feinberg, AP, Yeger, H & Williams, BRG 1990, 'Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor', Science, vol. 250, no. 4983, pp. 991-994.
Huang A, Campbell CE, Bonetta L, McAndrews-Hill MS, Chilton-Macneill S, Coppes MJ et al. Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor. Science. 1990 Nov 16;250(4983):991-994.
Huang, Annie ; Campbell, Christine E. ; Bonetta, Laura ; McAndrews-Hill, Monica S. ; Chilton-Macneill, Susan ; Coppes, Max J. ; Law, David J. ; Feinberg, Andrew P ; Yeger, Herman ; Williams, Bryan R G. / Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor. In: Science. 1990 ; Vol. 250, No. 4983. pp. 991-994.
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