Tissue correction for GABA-edited MRS

Considerations of voxel composition, tissue segmentation, and tissue relaxations

Research output: Contribution to journalArticle

Abstract

Purpose To develop a tissue correction for GABA-edited magnetic resonance spectroscopy (MRS) that appropriately addresses differences in voxel gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) fractions. Materials and Methods Simulations compared the performance of tissue correction approaches. Corrections were then applied to in vivo data from 16 healthy volunteers, acquired at 3T. GM, WM, and CSF fractions were determined from T1-weighted images. Corrections for CSF content, GM/WM GABA content, and water relaxation of the three compartments are combined into a single, fully corrected measurement. Results Simulations show that CSF correction increases the dependence of GABA measurements on GM/WM fraction, by an amount equal to the fraction of CSF. Furthermore, GM correction substantially (and nonlinearly) increases the dependence of GABA measurements on GM/WM fraction, for example, by a factor of over four when the voxel GM tissue fraction is 50%. At this tissue fraction, GABA is overestimated by a factor of 1.5. For the in vivo data, correcting for voxel composition increased measured GABA values (P0.5 for all regions). Corrected GABA values differ significantly based on the segmentation procedure used (P

Original languageEnglish (US)
Pages (from-to)1431-1440
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume42
Issue number5
DOIs
StatePublished - Nov 1 2015

Fingerprint

gamma-Aminobutyric Acid
Magnetic Resonance Spectroscopy
Cerebrospinal Fluid
Gray Matter
Healthy Volunteers
White Matter
Water

Keywords

  • GABA-edited MRS
  • tissue correction
  • tissue segmentation
  • voxel coregistration
  • voxel localization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{c96357a2f756414689123537c2f67c2a,
title = "Tissue correction for GABA-edited MRS: Considerations of voxel composition, tissue segmentation, and tissue relaxations",
abstract = "Purpose To develop a tissue correction for GABA-edited magnetic resonance spectroscopy (MRS) that appropriately addresses differences in voxel gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) fractions. Materials and Methods Simulations compared the performance of tissue correction approaches. Corrections were then applied to in vivo data from 16 healthy volunteers, acquired at 3T. GM, WM, and CSF fractions were determined from T1-weighted images. Corrections for CSF content, GM/WM GABA content, and water relaxation of the three compartments are combined into a single, fully corrected measurement. Results Simulations show that CSF correction increases the dependence of GABA measurements on GM/WM fraction, by an amount equal to the fraction of CSF. Furthermore, GM correction substantially (and nonlinearly) increases the dependence of GABA measurements on GM/WM fraction, for example, by a factor of over four when the voxel GM tissue fraction is 50{\%}. At this tissue fraction, GABA is overestimated by a factor of 1.5. For the in vivo data, correcting for voxel composition increased measured GABA values (P0.5 for all regions). Corrected GABA values differ significantly based on the segmentation procedure used (P",
keywords = "GABA-edited MRS, tissue correction, tissue segmentation, voxel coregistration, voxel localization",
author = "Harris, {Ashley D.} and Nicolaas Puts and Edden, {Richard Anthony Edward}",
year = "2015",
month = "11",
day = "1",
doi = "10.1002/jmri.24903",
language = "English (US)",
volume = "42",
pages = "1431--1440",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Tissue correction for GABA-edited MRS

T2 - Considerations of voxel composition, tissue segmentation, and tissue relaxations

AU - Harris, Ashley D.

AU - Puts, Nicolaas

AU - Edden, Richard Anthony Edward

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Purpose To develop a tissue correction for GABA-edited magnetic resonance spectroscopy (MRS) that appropriately addresses differences in voxel gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) fractions. Materials and Methods Simulations compared the performance of tissue correction approaches. Corrections were then applied to in vivo data from 16 healthy volunteers, acquired at 3T. GM, WM, and CSF fractions were determined from T1-weighted images. Corrections for CSF content, GM/WM GABA content, and water relaxation of the three compartments are combined into a single, fully corrected measurement. Results Simulations show that CSF correction increases the dependence of GABA measurements on GM/WM fraction, by an amount equal to the fraction of CSF. Furthermore, GM correction substantially (and nonlinearly) increases the dependence of GABA measurements on GM/WM fraction, for example, by a factor of over four when the voxel GM tissue fraction is 50%. At this tissue fraction, GABA is overestimated by a factor of 1.5. For the in vivo data, correcting for voxel composition increased measured GABA values (P0.5 for all regions). Corrected GABA values differ significantly based on the segmentation procedure used (P

AB - Purpose To develop a tissue correction for GABA-edited magnetic resonance spectroscopy (MRS) that appropriately addresses differences in voxel gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) fractions. Materials and Methods Simulations compared the performance of tissue correction approaches. Corrections were then applied to in vivo data from 16 healthy volunteers, acquired at 3T. GM, WM, and CSF fractions were determined from T1-weighted images. Corrections for CSF content, GM/WM GABA content, and water relaxation of the three compartments are combined into a single, fully corrected measurement. Results Simulations show that CSF correction increases the dependence of GABA measurements on GM/WM fraction, by an amount equal to the fraction of CSF. Furthermore, GM correction substantially (and nonlinearly) increases the dependence of GABA measurements on GM/WM fraction, for example, by a factor of over four when the voxel GM tissue fraction is 50%. At this tissue fraction, GABA is overestimated by a factor of 1.5. For the in vivo data, correcting for voxel composition increased measured GABA values (P0.5 for all regions). Corrected GABA values differ significantly based on the segmentation procedure used (P

KW - GABA-edited MRS

KW - tissue correction

KW - tissue segmentation

KW - voxel coregistration

KW - voxel localization

UR - http://www.scopus.com/inward/record.url?scp=84944900960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944900960&partnerID=8YFLogxK

U2 - 10.1002/jmri.24903

DO - 10.1002/jmri.24903

M3 - Article

VL - 42

SP - 1431

EP - 1440

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 5

ER -