Tissue characterization in cerebral ischemia using multiparameter MRI

H. S. Zadeh, R. Hammoud, Michael Jacobs, S. C. Patel, P. D. Mitsias, M. Pasnoor, R. Knight, Z. G. Zheng, M. Lu, M. Chopp

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

After pre-processing and segmentation, the proposed method scores tissue regions between 1 and N. Score 1 is assigned to normal white matter and score N to CSF. Lesion zones are assigned a score based on their relative levels of similarities to white matter and CSF. To evaluate the method, 15 rats were imaged by a 7T MRI system at one of the three time points (acute, sub-acute, chronic) after MCA occlusion. Then, they were sacrificed and their brains were sliced and prepared for histological studies. MRI of 2 or 3 slices of each rat brain, using 2 DWI (b = 400, b = 800), 1 PDWI, 1 T2WI, and 1 T1WI, was used and an MRI score between 1 and 100 (N = 100) was found for each region. Segmented regions were mapped onto the histology images and were scored by an experienced pathologist, from 1 to 10. MRI scores were validated using histology scores. To this end, correlation coefficients between the two scores (MRI and histology) were found. The results showed excellent correlations between MRI and histology scores at different time points.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsC. Chen, A.V. Clough
Pages387-398
Number of pages12
Volume4321
DOIs
StatePublished - 2001
Externally publishedYes
EventMedical Imaging 2001: Physiology and Function from Multidimensional Images - Sandiego, CA, United States
Duration: Feb 18 2001Feb 20 2001

Other

OtherMedical Imaging 2001: Physiology and Function from Multidimensional Images
CountryUnited States
CitySandiego, CA
Period2/18/012/20/01

Fingerprint

ischemia
histology
Magnetic resonance imaging
Histology
Tissue
rats
brain
Rats
occlusion
Brain
preprocessing
correlation coefficients
lesions
Processing

Keywords

  • Cerebral ischemia
  • ISODATA
  • Magnetic resonance imaging
  • Medical image analysis
  • MRI
  • Stroke
  • Tissue characterization

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Zadeh, H. S., Hammoud, R., Jacobs, M., Patel, S. C., Mitsias, P. D., Pasnoor, M., ... Chopp, M. (2001). Tissue characterization in cerebral ischemia using multiparameter MRI. In C. Chen, & A. V. Clough (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4321, pp. 387-398) https://doi.org/10.1117/12.428162

Tissue characterization in cerebral ischemia using multiparameter MRI. / Zadeh, H. S.; Hammoud, R.; Jacobs, Michael; Patel, S. C.; Mitsias, P. D.; Pasnoor, M.; Knight, R.; Zheng, Z. G.; Lu, M.; Chopp, M.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / C. Chen; A.V. Clough. Vol. 4321 2001. p. 387-398.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zadeh, HS, Hammoud, R, Jacobs, M, Patel, SC, Mitsias, PD, Pasnoor, M, Knight, R, Zheng, ZG, Lu, M & Chopp, M 2001, Tissue characterization in cerebral ischemia using multiparameter MRI. in C Chen & AV Clough (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4321, pp. 387-398, Medical Imaging 2001: Physiology and Function from Multidimensional Images, Sandiego, CA, United States, 2/18/01. https://doi.org/10.1117/12.428162
Zadeh HS, Hammoud R, Jacobs M, Patel SC, Mitsias PD, Pasnoor M et al. Tissue characterization in cerebral ischemia using multiparameter MRI. In Chen C, Clough AV, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4321. 2001. p. 387-398 https://doi.org/10.1117/12.428162
Zadeh, H. S. ; Hammoud, R. ; Jacobs, Michael ; Patel, S. C. ; Mitsias, P. D. ; Pasnoor, M. ; Knight, R. ; Zheng, Z. G. ; Lu, M. ; Chopp, M. / Tissue characterization in cerebral ischemia using multiparameter MRI. Proceedings of SPIE - The International Society for Optical Engineering. editor / C. Chen ; A.V. Clough. Vol. 4321 2001. pp. 387-398
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