Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men

Ashley E. Ross, Michael Johnson, Kasra Yousefi, Elai Davicioni, George J. Netto, Luigi Marchionni, Helen L. Fedor, Stephanie Glavaris, Voleak Choeurng, Christine Buerki, Nicholas Erho, Lucia L. Lam, Elizabeth B. Humphreys, Sheila Faraj, Stephania M. Bezerra, Misop Han, Alan Wayne Partin, Bruce Trock, Edward M. Schaeffer

Research output: Contribution to journalArticle

Abstract

Background Radical prostatectomy (RP) is a primary treatment option for men with intermediate- and high-risk prostate cancer. Although many are effectively cured with local therapy alone, these men are by definition at higher risk of adverse pathologic features and clinical disease recurrence. It has been shown that the Decipher test predicts metastatic progression in cohorts that received adjuvant and salvage therapy following RP. Objective To evaluate the Decipher genomic classifier in a natural history cohort of men at risk who received no additional treatment until the time of metastatic progression. Design, setting, and participants Retrospective case-cohort design for 356 men who underwent RP between 1992 and 2010 at intermediate or high risk and received no additional treatment until the time of metastasis. Participants met the following criteria: (1) Cancer of the Prostate Risk Assessment postsurgical (CAPRA-S) score ≥3; (2) pathologic Gleason score ≥7; and (3) post-RP prostate-specific antigen nadir

Original languageEnglish (US)
Pages (from-to)157-165
Number of pages9
JournalEuropean Urology
Volume69
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Prostatectomy
Genomics
Natural History
Prostatic Neoplasms
Salvage Therapy
Neoplasm Grading
Therapeutics
Prostate-Specific Antigen
Neoplasm Metastasis
Recurrence

Keywords

  • Genomic classifier
  • Metastasis
  • Prognosis
  • Prostate cancer
  • Transcriptome

ASJC Scopus subject areas

  • Urology

Cite this

Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men. / Ross, Ashley E.; Johnson, Michael; Yousefi, Kasra; Davicioni, Elai; Netto, George J.; Marchionni, Luigi; Fedor, Helen L.; Glavaris, Stephanie; Choeurng, Voleak; Buerki, Christine; Erho, Nicholas; Lam, Lucia L.; Humphreys, Elizabeth B.; Faraj, Sheila; Bezerra, Stephania M.; Han, Misop; Partin, Alan Wayne; Trock, Bruce; Schaeffer, Edward M.

In: European Urology, Vol. 69, No. 1, 01.01.2016, p. 157-165.

Research output: Contribution to journalArticle

Ross, AE, Johnson, M, Yousefi, K, Davicioni, E, Netto, GJ, Marchionni, L, Fedor, HL, Glavaris, S, Choeurng, V, Buerki, C, Erho, N, Lam, LL, Humphreys, EB, Faraj, S, Bezerra, SM, Han, M, Partin, AW, Trock, B & Schaeffer, EM 2016, 'Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men', European Urology, vol. 69, no. 1, pp. 157-165. https://doi.org/10.1016/j.eururo.2015.05.042
Ross, Ashley E. ; Johnson, Michael ; Yousefi, Kasra ; Davicioni, Elai ; Netto, George J. ; Marchionni, Luigi ; Fedor, Helen L. ; Glavaris, Stephanie ; Choeurng, Voleak ; Buerki, Christine ; Erho, Nicholas ; Lam, Lucia L. ; Humphreys, Elizabeth B. ; Faraj, Sheila ; Bezerra, Stephania M. ; Han, Misop ; Partin, Alan Wayne ; Trock, Bruce ; Schaeffer, Edward M. / Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men. In: European Urology. 2016 ; Vol. 69, No. 1. pp. 157-165.
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