Tissue antibiotic penetration in streptococcal gangrene

J. R. Graybill, D. N. Pierson, P. Charache

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The high mortality of streptococcal gangrene was not dramatically reduced by penicillin therapy. Tissue antibiotic penetration was measured in a patient who ultimately succumbed to complications of this disease. High antibiotic levels were found in muscle that subsequently became gangrenous. This suggests that retained streptococcal products produce a continuing inflammatory process with ultimate necrosis of involved structures. Aggressive debridement remains the mainstay of therapy.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalJohns Hopkins Medical Journal
Issue number1
StatePublished - 1973

ASJC Scopus subject areas

  • Medicine(all)


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