Tissue antibiotic penetration in streptococcal gangrene

J. R. Graybill, D. N. Pierson, P. Charache

Research output: Contribution to journalArticlepeer-review

Abstract

The high mortality of streptococcal gangrene was not dramatically reduced by penicillin therapy. Tissue antibiotic penetration was measured in a patient who ultimately succumbed to complications of this disease. High antibiotic levels were found in muscle that subsequently became gangrenous. This suggests that retained streptococcal products produce a continuing inflammatory process with ultimate necrosis of involved structures. Aggressive debridement remains the mainstay of therapy.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalJohns Hopkins Medical Journal
Volume133
Issue number1
StatePublished - 1973

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Tissue antibiotic penetration in streptococcal gangrene'. Together they form a unique fingerprint.

Cite this